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<p>Curcumin is a natural polyphenol with well-documented antioxidant and anti-inflammatory properties; however, its therapeutic application in wound healing is limited by poor aqueous solubility and instability. In the present study, curcumin was successfully encapsulated into a graphene oxide–mesoporous silica nanocomposite (CU–GO–MSN) synthesized via a one-pot method and evaluated for wound management applications. UV–Visible spectroscopy confirmed the reduction of graphene oxide and effective curcumin loading, while FTIR analysis demonstrated strong intermolecular interactions between curcumin, GO, and MSN. SEM and EDX analyses revealed uniform dispersion of mesoporous silica within GO sheets and a significant increase in carbon content after curcumin encapsulation. BET and SAXS studies confirmed a highly ordered mesoporous structure with a large surface area (763&#xa0;m²/g), supporting high drug loading (14.62 ± 0.85%) and entrapment efficiency (78.34 ± 1.27%). The CU–GO–MSN nanocomposite exhibited significantly enhanced antibacterial activity compared to GO and curcumin alone. In vitro release studies demonstrated sustained curcumin release from the film-forming gel, indicating controlled drug diffusion. Furthermore, the CAM assay revealed dose-dependent angiogenesis, confirming the nanocomposite’s pro-healing potential. Overall, the findings demonstrate that CU–GO–MSN acts as a multifunctional nanoplatform combining structural stability, sustained drug release, antimicrobial activity, and angiogenic stimulation, highlighting its strong potential for advanced wound healing applications.</p>

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Curcumin-Loaded MSN@GO Nanocomposites: Fabrication, Characterization, and Assessment for Wound Management

  • 期刊论文

  • 发表日期：

    2026年4月7日

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  • Bhushan R. Dravyakar,
  • Kunal B. Bachchhao,
  • Kumar Pratyush,
  • Priya Dule,
  • Rupesh K. More,
  • Vedant Shimpi,
  • Sakshi Nakade,
  • Atul Sherje

摘要

Curcumin is a natural polyphenol with well-documented antioxidant and anti-inflammatory properties; however, its therapeutic application in wound healing is limited by poor aqueous solubility and instability. In the present study, curcumin was successfully encapsulated into a graphene oxide–mesoporous silica nanocomposite (CU–GO–MSN) synthesized via a one-pot method and evaluated for wound management applications. UV–Visible spectroscopy confirmed the reduction of graphene oxide and effective curcumin loading, while FTIR analysis demonstrated strong intermolecular interactions between curcumin, GO, and MSN. SEM and EDX analyses revealed uniform dispersion of mesoporous silica within GO sheets and a significant increase in carbon content after curcumin encapsulation. BET and SAXS studies confirmed a highly ordered mesoporous structure with a large surface area (763 m²/g), supporting high drug loading (14.62 ± 0.85%) and entrapment efficiency (78.34 ± 1.27%). The CU–GO–MSN nanocomposite exhibited significantly enhanced antibacterial activity compared to GO and curcumin alone. In vitro release studies demonstrated sustained curcumin release from the film-forming gel, indicating controlled drug diffusion. Furthermore, the CAM assay revealed dose-dependent angiogenesis, confirming the nanocomposite’s pro-healing potential. Overall, the findings demonstrate that CU–GO–MSN acts as a multifunctional nanoplatform combining structural stability, sustained drug release, antimicrobial activity, and angiogenic stimulation, highlighting its strong potential for advanced wound healing applications.