<p>A controlled-release hydrogel system for dermal wound repair was developed, consisting of Quercetin (QCT) encapsulated in polymeric micelles and embedded in a thermosensitive hydrogel network. Quercetin, a bioactive flavonoid with potent antioxidant and anti-inflammatory activities, exhibits limited aqueous solubility. This limitation was successfully addressed by encapsulating Quercetin within chitosan-grafted-aspartic acid polymeric micelles (QCT-M), resulting in enhanced drug loading and superior encapsulation efficiency. The resulting thermo-responsive hydrogel containing QCT-M (QCT-M-H) was formulated as a topical wound dressing designed to facilitate enhanced dermal tissue regeneration. Initially, the QCT-M-H formulation existed as a free-flowing sol, which transitioned to a non-flowing gel at physiological temperature upon incorporation of a cross-linking agent and subsequent incubation for 24&#xa0;h. In vitro evaluations demonstrated that QCT-M-H exhibited excellent tissue adhesiveness and sustained QCT release over an extended period. The in vivo efficacy of QCT-M-H was assessed using a burn wound model, where it significantly promoted wound healing. Integration of QCT into the hydrogel matrix facilitated the formation of a structured epidermal layer with mature collagen deposition, thereby accelerating wound repair. The QCT-M-H hydrogel system, with its favorable mechanical properties, antibacterial activity, and biocompatibility, offers a promising platform for enhanced wound-healing applications.</p> Graphical Abstract <p></p>