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<p>A curcumin-loaded peppermint oil nanoemulsion (CUR-PONE) was formulated via probe sonication using Tween 80 (T80) to enhance curcumin’s solubility and therapeutic efficacy. TEM and DLS revealed uniform, negatively charged droplets with sizes of 17.08 ± 1.35&#xa0;nm (PDI 0.497 ± 0.002) for PONE and 16.88 ± 1.63&#xa0;nm (PDI 0.475 ± 0.005) for CUR-PONE, with viscosity and conductivity verifying oil-in-water system. UV-Vis spectrophotometry measured 92.77% entrapment efficiency, while DSC confirmed CUR amorphization within nanoemulsion droplets. CUR-PONE showed enhanced photostability against UV degradation (6.01%) compared to curcumin in ethanol (69.99%) and maintained stability for 30 days. Spectroscopic and docking studies indicated strong binding to bovine serum albumin (BSA) through electrostatic and hydrophobic interactions. Sustained, pH-dependent release followed Korsmeyer–Peppas and Higuchi models, with 18.57% and 79.09% release at pH 7.4 and 5.5, respectively. CUR-PONE exhibited potent antioxidant activity (IC<sub>50</sub> = 0.236&#xa0;µg/ml), antimicrobial efficacy, and gel biocompatibility. The study establishes CUR-PONE as a stable, effective nanoemulsion for improving curcumin’s solubility, stability, and therapeutic performance.</p> Graphical Abstract <p></p>

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Optimized Peppermint Oil-Tween 80 Nanoemulsion Enables Superior Curcumin Retention, Antioxidant Efficacy, and Biocompatibility

  • 期刊论文

  • 发表日期：

    2026年3月28日

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  • Indu D. Mishra,
  • Pawan Sharma,
  • Sagar Barage,
  • Renitta Jobby,
  • Ahmad Ali,
  • Shilpee Sachar

摘要

A curcumin-loaded peppermint oil nanoemulsion (CUR-PONE) was formulated via probe sonication using Tween 80 (T80) to enhance curcumin’s solubility and therapeutic efficacy. TEM and DLS revealed uniform, negatively charged droplets with sizes of 17.08 ± 1.35 nm (PDI 0.497 ± 0.002) for PONE and 16.88 ± 1.63 nm (PDI 0.475 ± 0.005) for CUR-PONE, with viscosity and conductivity verifying oil-in-water system. UV-Vis spectrophotometry measured 92.77% entrapment efficiency, while DSC confirmed CUR amorphization within nanoemulsion droplets. CUR-PONE showed enhanced photostability against UV degradation (6.01%) compared to curcumin in ethanol (69.99%) and maintained stability for 30 days. Spectroscopic and docking studies indicated strong binding to bovine serum albumin (BSA) through electrostatic and hydrophobic interactions. Sustained, pH-dependent release followed Korsmeyer–Peppas and Higuchi models, with 18.57% and 79.09% release at pH 7.4 and 5.5, respectively. CUR-PONE exhibited potent antioxidant activity (IC50 = 0.236 µg/ml), antimicrobial efficacy, and gel biocompatibility. The study establishes CUR-PONE as a stable, effective nanoemulsion for improving curcumin’s solubility, stability, and therapeutic performance.

Graphical Abstract