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<p>Combating multidrug-resistant pathogen strains is a critical area of ​​modern biomedicine. Lack of control over antibiotic dispensing and their excessive use has led to the emergence of super-strains resistant to a range of existing antibiotics. Finding alternative methods to combat these strains that eliminate the possibility of developing resistance is particularly important. One of the optimal strategies for improving healthcare is the management of wound infections, which are the primary consequences of surgical interventions and injuries. We present a comprehensive study of the effect of moist wound dressings with imbedded silver, copper and selenium nanoparticles based on glycerol and silicone oil on the healing of infected wounds in Balb/c mice. Wound infections were formed using two- and three-component biofilms, including gram-positive (<i>S. aureus</i>,<i> S. epidermidis</i>) and gram-negative (<i>E. coli</i>,<i> K. pneumoniae</i>) bacteria. Moist NP-based wound dressings were fabricated by soaking the commercially available sterile dressings with Ag and Cu NPs in glycerol and Se NPs in silicone oil. Microbiological evaluation revealed very scanty growth (up to 10 colonies) and scanty growth (10–25 colonies) at the 6–9 days of observation in the group treated with NPs versus 9–12 days in the control group. Positive dynamics of the percentage wound area reduction was observed after application of moist NP-based wound dressings. The data obtained may be used in the further evaluation of the moist wound dressings’ importance in the chronical wounds’ treatment.</p>

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Wound Infections’ Treatment with Nanoparticles-Embedded Dressings: Pilot Studies of the Effect on the Multi-Species Bacterial Wound Infections in vivo

  • 期刊论文

  • 发表日期：

    2026年3月17日

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  • Irina Saraeva,
  • Eteri Tolordava,
  • Darya Pozdnyakova,
  • Sergey Kudryashov

摘要

Combating multidrug-resistant pathogen strains is a critical area of ​​modern biomedicine. Lack of control over antibiotic dispensing and their excessive use has led to the emergence of super-strains resistant to a range of existing antibiotics. Finding alternative methods to combat these strains that eliminate the possibility of developing resistance is particularly important. One of the optimal strategies for improving healthcare is the management of wound infections, which are the primary consequences of surgical interventions and injuries. We present a comprehensive study of the effect of moist wound dressings with imbedded silver, copper and selenium nanoparticles based on glycerol and silicone oil on the healing of infected wounds in Balb/c mice. Wound infections were formed using two- and three-component biofilms, including gram-positive (S. aureus, S. epidermidis) and gram-negative (E. coli, K. pneumoniae) bacteria. Moist NP-based wound dressings were fabricated by soaking the commercially available sterile dressings with Ag and Cu NPs in glycerol and Se NPs in silicone oil. Microbiological evaluation revealed very scanty growth (up to 10 colonies) and scanty growth (10–25 colonies) at the 6–9 days of observation in the group treated with NPs versus 9–12 days in the control group. Positive dynamics of the percentage wound area reduction was observed after application of moist NP-based wound dressings. The data obtained may be used in the further evaluation of the moist wound dressings’ importance in the chronical wounds’ treatment.