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<p>Nanotechnology has reached advanced levels given the possibility of optimizing functions, which results in products which are economically viable, sustainable and efficient. Natural compounds have been considered in recent years in the form of nanoparticles as a method of improving therapy and preventive processes in medicine. Platinum nanoparticles (PtNPs) are also distinguished among noble metals as they are catalysts and have low toxicity. Tannic acid (TA) is a natural polyphenol that is an antioxidant, and polyvinylpyrrolidone (PVP) is a hydrophilic polymer that is commonly used as a carrier in drugs. This paper reports a green synthesis technique of preparing platinum nanoparticles using tannic acid and polyvinylpyrrolidone (PtNPs-TA-PVP). FTIR, SEM, XRD, and UV-Vis spectroscopy were used to characterize the nanocomposite. The mean size of PtNPs-TA-PVP was 35.1&#xa0;nm, antioxidant ability of 71.5% and high antibacterial properties with a 24&#xa0;mm (<i>E. coli</i>) and 27&#xa0;mm (<i>S. aureus</i>) inhibition zone. The lowest concentration of the compound that inhibited the growth of <i>E. coli</i> was 0.3% and the mixture decreased the biofilm formation up to 70%. These findings indicate the possibility of PtNPs-TA-PVP as a multifunctional drug delivery, antioxidant, and antimicrobial agent.</p>

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Synthesis and Characterization of Platinum Nanoparticles with Tannic Acid and Polyvinylpyrrolidone Nanocomposite Towards Medical Applications

  • 期刊论文

  • 发表日期：

    2026年3月17日

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  • Noor Qasim Ibrahim,
  • Layla M. Hasan,
  • Lubna Ghalib

摘要

Nanotechnology has reached advanced levels given the possibility of optimizing functions, which results in products which are economically viable, sustainable and efficient. Natural compounds have been considered in recent years in the form of nanoparticles as a method of improving therapy and preventive processes in medicine. Platinum nanoparticles (PtNPs) are also distinguished among noble metals as they are catalysts and have low toxicity. Tannic acid (TA) is a natural polyphenol that is an antioxidant, and polyvinylpyrrolidone (PVP) is a hydrophilic polymer that is commonly used as a carrier in drugs. This paper reports a green synthesis technique of preparing platinum nanoparticles using tannic acid and polyvinylpyrrolidone (PtNPs-TA-PVP). FTIR, SEM, XRD, and UV-Vis spectroscopy were used to characterize the nanocomposite. The mean size of PtNPs-TA-PVP was 35.1 nm, antioxidant ability of 71.5% and high antibacterial properties with a 24 mm (E. coli) and 27 mm (S. aureus) inhibition zone. The lowest concentration of the compound that inhibited the growth of E. coli was 0.3% and the mixture decreased the biofilm formation up to 70%. These findings indicate the possibility of PtNPs-TA-PVP as a multifunctional drug delivery, antioxidant, and antimicrobial agent.