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<p>Wound healing in diabetic patients often present significant risks. Currently, the treatment is confined to oral antibiotic therapy along with use of dressings which shows inadequate efficacy and patient compliance. To overcome these challenge film forming gel (FFG-Z) was prepared containing several important drugs &amp; ingredients that will treat the diabetic wound within 20 days. Silver nanoparticles were prepared by using Turkevich method and loaded into gel based on Chitosan, Polyvinyl alcohol and Hydroxyl ethyl cellulose along with Linezolid and Rosuvastatin. Prepared FFG-Z was evaluated for their in-vitro and in-vivo characterization includes, Morphological evaluation, size distribution, FTIR, thermal analysis, Irritation study and diabetic wound recovery. pH of prepared patch was 6.85 ± 0.25 and having 1302 ± 23 mPas.S viscosity. Spreadability was 5.83 ± 0.72 gcm/sec. Moreover, the FFG-Z demonstrated pseudo plastic, non-Newtonian flow and prolonged drug release. Besides, prepared nanoparticles exhibited a particle size of 475 ± 25&#xa0;nm and zeta potential of 1.4mV. SEM analysis confirmed the uniform distribution of elongated, rod shaped nanoparticles. FTIR determined constituent compatibility. DSC and TGA demonstrated thermal stability of the formulation. Topical use of prepared FFG-Z on diabetic wounds in rats demonstrated advanced wound healing within 20 days. The primary results showed that the Linezolid, Rosuvastatin and silver nanoparticles loaded FFG-Z can be prepared as a magnificent applicant for the management of diabetic wounds.</p>

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Preparation and Evaluation of Silver Nanoparticles Loaded Film Forming Gel; Co-Delivering Linezolid and Rosuvastatin for Diabetic Foot Wound

  • 期刊论文

  • 发表日期：

    2026年3月5日

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  • Salwa Zafar,
  • Zulcaif,
  • Asif Mahmood,
  • Rai Muhammad Sarfraz,
  • Muhammad Imran Khan,
  • Shahid Rasool

摘要

Wound healing in diabetic patients often present significant risks. Currently, the treatment is confined to oral antibiotic therapy along with use of dressings which shows inadequate efficacy and patient compliance. To overcome these challenge film forming gel (FFG-Z) was prepared containing several important drugs & ingredients that will treat the diabetic wound within 20 days. Silver nanoparticles were prepared by using Turkevich method and loaded into gel based on Chitosan, Polyvinyl alcohol and Hydroxyl ethyl cellulose along with Linezolid and Rosuvastatin. Prepared FFG-Z was evaluated for their in-vitro and in-vivo characterization includes, Morphological evaluation, size distribution, FTIR, thermal analysis, Irritation study and diabetic wound recovery. pH of prepared patch was 6.85 ± 0.25 and having 1302 ± 23 mPas.S viscosity. Spreadability was 5.83 ± 0.72 gcm/sec. Moreover, the FFG-Z demonstrated pseudo plastic, non-Newtonian flow and prolonged drug release. Besides, prepared nanoparticles exhibited a particle size of 475 ± 25 nm and zeta potential of 1.4mV. SEM analysis confirmed the uniform distribution of elongated, rod shaped nanoparticles. FTIR determined constituent compatibility. DSC and TGA demonstrated thermal stability of the formulation. Topical use of prepared FFG-Z on diabetic wounds in rats demonstrated advanced wound healing within 20 days. The primary results showed that the Linezolid, Rosuvastatin and silver nanoparticles loaded FFG-Z can be prepared as a magnificent applicant for the management of diabetic wounds.