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<p>In recent years, the use of nanomaterials in cancer therapy has gained significant attention due to their unique physicochemical properties. This study focuses on the synthesis of vanadium disulfide nanoparticles (VS<sub>2</sub>NPs) via the solvothermal route, followed by their characterization and evaluation of anticancer activity against MCF-7 breast cancer cells. XRD, UV-Vis, FTIR, FESEM, and EDS investigations were used to find out the structural, morphological, and optical properties of the material. With an average crystallite size of about 41.22&#xa0;nm and a band gap of 3.88&#xa0;eV, the results indicated a hexagonal shape, suggesting their potential for biological applications. The cytotoxicity of the synthesized VS<sub>2</sub> nanoparticles was assessed using the MTT assay. The results indicated the anti-proliferative effect of VS₂ nanoparticles toward MCF-7 cells with an IC₅₀ value of 34.55&#xa0;µg/mL. Moreover, the synthesized VS2 induced apoptosis in the breast cancer cells, MCF-7, as confirmed by acridine orange/propidium iodide (AO/PI) staining and demonstrating morphological alterations including cell shrinkage and the formation of apoptotic bodies. The genotoxicity of the prepared nanoparticles, VS<sub>2</sub> nanoparticles, was evaluated using a comet assay, indicating DNA fragmentation and gene-damaging effects. The molecular docking simulation study was used to predict the stability of the nanoparticle-receptor complex under physiological conditions.</p>

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Solvothermal Synthesis and Characterization of VS₂ Nanoparticles: MCF-7 Anticancer Activity and Molecular Docking Insights

  • 期刊论文

  • 发表日期：

    2026年3月3日

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  • Zahraa A. Kadhim,
  • Ali F. Zbala,
  • Rana A. Hikmet,
  • Maryam D. Kamel,
  • Ghassan M. Sulaiman,
  • Duha S. Ahmed,
  • Majid S. Jabir,
  • Hamdoon A. Mohammed

摘要

In recent years, the use of nanomaterials in cancer therapy has gained significant attention due to their unique physicochemical properties. This study focuses on the synthesis of vanadium disulfide nanoparticles (VS2NPs) via the solvothermal route, followed by their characterization and evaluation of anticancer activity against MCF-7 breast cancer cells. XRD, UV-Vis, FTIR, FESEM, and EDS investigations were used to find out the structural, morphological, and optical properties of the material. With an average crystallite size of about 41.22 nm and a band gap of 3.88 eV, the results indicated a hexagonal shape, suggesting their potential for biological applications. The cytotoxicity of the synthesized VS2 nanoparticles was assessed using the MTT assay. The results indicated the anti-proliferative effect of VS₂ nanoparticles toward MCF-7 cells with an IC₅₀ value of 34.55 µg/mL. Moreover, the synthesized VS2 induced apoptosis in the breast cancer cells, MCF-7, as confirmed by acridine orange/propidium iodide (AO/PI) staining and demonstrating morphological alterations including cell shrinkage and the formation of apoptotic bodies. The genotoxicity of the prepared nanoparticles, VS2 nanoparticles, was evaluated using a comet assay, indicating DNA fragmentation and gene-damaging effects. The molecular docking simulation study was used to predict the stability of the nanoparticle-receptor complex under physiological conditions.