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<p>Developing biocompatible wound dressings is essential for improving healing efficiency and patient comfort such as SA-HA-Col 93, SA-HA-Col 66, and SA-HA-Col 39 films were synthesized using varying quantities of 1% hyaluronic acid (HA), 0.1% collagen, and 1% sodium alginate (SA). SA-HA-COL 93 was loaded with GA (GA). GA acid displays various advantageous characteristics such as antioxidant, anti-inflammatory, ad antibacterial. Structural characterization using FTIR, SEM, and TGA confirmed successful polymer crosslinking, uniform GA incorporation, and good thermal stability. The addition of GA produced a semi-porous, flexible network with excellent swelling ability (325%) and suitable water vapor permeability (273&#xa0;g/m²/day), ensuring effective moisture balance at the wound interface. Although tensile strength decreased slightly from 0.18 to 0.16&#xa0;MPa, the films maintained sufficient elasticity. Biological assessments demonstrated that the GA-loaded film exhibited strong antioxidant activity (55.8%), potent antibacterial effects against <i>S. aureus</i> (95%) and <i>E. coli</i> (90%), and higher fibroblast cell viability (73.45%) compared to the blank film (60.35%), confirming its excellent biocompatibility. The kinetics of GA release from the loaded wound dressing films were also examined using various models. The drug release profile followed a biphasic pattern, with 73.89% GA released within 10&#xa0;h, fitting best to the Hixson–Crowell model (R² = 0.994). Altogether, these findings demonstrate that incorporating GA into the SA–HA–Col matrix significantly enhances the film’s bioactivity, safety, and therapeutic performance. The resulting GA-loaded SA–HA–Col dressing offers an ideal combination of controlled drug delivery, antioxidant protection, and antibacterial functionality, making it a promising material for advanced wound healing and skin tissue regeneration.</p> Graphical Abstract <p></p>

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GA–Loaded Wound Dressing bas Ed on Hyaluronic Acid with Antioxidant and Antibacterial Activities

  • 期刊论文

  • 发表日期：

    2026年2月26日

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  • A. Abou-Okeil,
  • Ghada M. Taha

摘要

Developing biocompatible wound dressings is essential for improving healing efficiency and patient comfort such as SA-HA-Col 93, SA-HA-Col 66, and SA-HA-Col 39 films were synthesized using varying quantities of 1% hyaluronic acid (HA), 0.1% collagen, and 1% sodium alginate (SA). SA-HA-COL 93 was loaded with GA (GA). GA acid displays various advantageous characteristics such as antioxidant, anti-inflammatory, ad antibacterial. Structural characterization using FTIR, SEM, and TGA confirmed successful polymer crosslinking, uniform GA incorporation, and good thermal stability. The addition of GA produced a semi-porous, flexible network with excellent swelling ability (325%) and suitable water vapor permeability (273 g/m²/day), ensuring effective moisture balance at the wound interface. Although tensile strength decreased slightly from 0.18 to 0.16 MPa, the films maintained sufficient elasticity. Biological assessments demonstrated that the GA-loaded film exhibited strong antioxidant activity (55.8%), potent antibacterial effects against S. aureus (95%) and E. coli (90%), and higher fibroblast cell viability (73.45%) compared to the blank film (60.35%), confirming its excellent biocompatibility. The kinetics of GA release from the loaded wound dressing films were also examined using various models. The drug release profile followed a biphasic pattern, with 73.89% GA released within 10 h, fitting best to the Hixson–Crowell model (R² = 0.994). Altogether, these findings demonstrate that incorporating GA into the SA–HA–Col matrix significantly enhances the film’s bioactivity, safety, and therapeutic performance. The resulting GA-loaded SA–HA–Col dressing offers an ideal combination of controlled drug delivery, antioxidant protection, and antibacterial functionality, making it a promising material for advanced wound healing and skin tissue regeneration.

Graphical Abstract