Scholarlink

<p>This study describes the fabrication of functional nanofibers via electrospinning by embedding tetra-substituted metallophthalocyanines (CoPc, CuPc, MnClPc) into a poly(acrylonitrile-co-vinyl acetate) (PAN) matrix. Comprehensive characterization with UV-Vis, FTIR, FE-SEM, EDX, and thermal analysis demonstrated the successful incorporation of phthalocyanines, resulting in smooth, homogenous nanofibers with consistent component distribution and improved thermal stability. Biological assessments demonstrated significant biomedical and biotechnological potential. In assessments associated with diabetes therapy, MnClPc/PAN had a dual-mode action on α-amylase, showing both activation (22.29 ± 1.43% increase) and noticeable inhibition (up to 73.59 ± 3.82%). Furthermore, all operational nanofibers effectively cleaved pBR322 plasmid DNA, and complete degradation was achieved at concentrations ranging from 100 to 200&#xa0;mg/L. Antimicrobial studies revealed moderate antibacterial effectiveness and a significant decrease in biofilm formation, with MnClPc/PAN showing the highest inhibition rates of 66.17 ± 3.83% against S. aureus and 76.85 ± 4.48% against <i>P. aeruginosa</i>. CoPc/PAN significantly decreased the vitality of <i>E. coli</i> by 75.65 ± 4.33% in under dark conditions and by 85.02 ± 4.97% after photodynamic treatment. The findings demonstrated that the developed nanofibers, MnClPc/PAN and CoPc/PAN show promise as candidates for improved wound dressings and smart drug delivery systems.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Multifunctional Electrospun Nanofibers Embedded with Metallophthalocyanines for Biomedical Applications: Antidiabetic, Antimicrobial, and DNA Cleavage Activities

  • 期刊论文

  • 发表日期：

    2026年2月18日

查看全文
  • Yusuf Yılmaz,
  • Fatma Aytan Kılıçarslan,
  • Ali Erdoğmuş,
  • M. Serkan Yalçın,
  • Serpil Gonca,
  • Sadin Özdemir

摘要

This study describes the fabrication of functional nanofibers via electrospinning by embedding tetra-substituted metallophthalocyanines (CoPc, CuPc, MnClPc) into a poly(acrylonitrile-co-vinyl acetate) (PAN) matrix. Comprehensive characterization with UV-Vis, FTIR, FE-SEM, EDX, and thermal analysis demonstrated the successful incorporation of phthalocyanines, resulting in smooth, homogenous nanofibers with consistent component distribution and improved thermal stability. Biological assessments demonstrated significant biomedical and biotechnological potential. In assessments associated with diabetes therapy, MnClPc/PAN had a dual-mode action on α-amylase, showing both activation (22.29 ± 1.43% increase) and noticeable inhibition (up to 73.59 ± 3.82%). Furthermore, all operational nanofibers effectively cleaved pBR322 plasmid DNA, and complete degradation was achieved at concentrations ranging from 100 to 200 mg/L. Antimicrobial studies revealed moderate antibacterial effectiveness and a significant decrease in biofilm formation, with MnClPc/PAN showing the highest inhibition rates of 66.17 ± 3.83% against S. aureus and 76.85 ± 4.48% against P. aeruginosa. CoPc/PAN significantly decreased the vitality of E. coli by 75.65 ± 4.33% in under dark conditions and by 85.02 ± 4.97% after photodynamic treatment. The findings demonstrated that the developed nanofibers, MnClPc/PAN and CoPc/PAN show promise as candidates for improved wound dressings and smart drug delivery systems.