One-Pot Solvothermal Synthesis and the Biological Studies of Mn - Co Metal-Organic Frameworks
摘要
Metal-organic frameworks (MOFs) have been used in microbial studies and as antioxidants but the use of bimetallic MOFs for microbial and antioxidant studies has been rarely reported or found no records in the literature. Hence in this study, we have focused on synthesis of the monometallic Mn MOF and bimetallic Mn-Co MOF using terephthalic acid (BDC) as a linker molecule by the one-pot solvothermal route. The successfully synthesized MOFs were characterized by X-ray diffraction (XRD), attenuated total reflection with Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray (EDX) analysis, ultraviolet-visible diffuse reflectance spectroscopy (UV-vis DRS), and photoluminescence (PL) studies. These MOF samples were subjected to microbial and antioxidant studies. The antibacterial studies exhibited a maximum zone of inhibition of 12.33 mm for Mn-BDC and 17.33 mm for Mn-Co-BDC against S. aureus, and 18.33 mm for Mn-BDC and 16.33 mm for Mn-Co-BDC against E. coli. Whereas for antifungal activity, Mn-BDC did not show any activity, but Mn-Co-BDC exhibited a maximum zone of inhibition of 19.33 mm at a 400-µg concentration for A. flavus fungus. Antioxidant property of the synthesized material was evaluated using the DPPH assay method, and the IC50 value was found to be 26.14 µg/mL for Mn-BDC and 18.605 µg/mL for Mn-Co-BDC. From the above experiments, the synthesized bimetallic MOF exhibits significant inhibition of both bacterial and fungal growth, making it a potential candidate for combating microbial infections. Additionally, the MOF demonstrates antioxidant properties. The MOFs were subjected to cytotoxicity assay on MCF-7 cell lines. The percentage (%) cytotoxicity of Mn-BDC and Mn-Co-BDC was found to be 117 µg/mL and 65.9 µg/Ml respectively indicating that the synthesized MOFs are safe to the cells for in vivo use.