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<p>In this study, a multifunctional nanocomposite was prepared by integrating core–shell structured Fe₃O₄ nanoparticles with a layer of L-Carnitine (LC), designed to improve biocompatibility, magnetic responsiveness, and antibacterial activity for biomedical use. FTIR analysis confirmed successful functionalisation of L-Carnitine through characteristic functional groups, while XRD revealed a highly crystalline inverse spinel structure of Fe₃O₄. FE-SEM and HR-TEM images demonstrated spherical morphology featuring Fe₃O₄ functionalised with L-Carnitine, with a range of 13.7 ± 4.55&#xa0;nm and 13.57 ± 4.16&#xa0;nm, respectively. TGA indicated thermal stability and inferred the presence of organic content, supporting effective surface modification. VSM analysis confirmed a superparamagnetic nature with decreased magnetic saturation due to the LC coating. The prepared nanocomposite was examined for anti-bacterial activity, and the LC@Fe₃O₄ nanocomposite showed strong antibacterial activity against both gram-positive and gram-negative bacterial strains. Cytotoxicity assays on MDA-MB-231 cells confirmed excellent anti-cancer properties.</p> Graphical Abstract <p></p>

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L-Carnitine Functionalized Iron Oxide (LC@Fe₃O₄) Nanocomposites: Synthesis, Characterisation and Applications in Antibacterial and Anticancer Activity

  • 期刊论文

  • 发表日期：

    2026年2月21日

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  • Mariyappan Yogeshwari,
  • Dhanasekaran Suraksha,
  • Devendiran Parthiban,
  • Devarapalli Chenna Rao,
  • Muniyan Ramasamy Kuppusamy

摘要

In this study, a multifunctional nanocomposite was prepared by integrating core–shell structured Fe₃O₄ nanoparticles with a layer of L-Carnitine (LC), designed to improve biocompatibility, magnetic responsiveness, and antibacterial activity for biomedical use. FTIR analysis confirmed successful functionalisation of L-Carnitine through characteristic functional groups, while XRD revealed a highly crystalline inverse spinel structure of Fe₃O₄. FE-SEM and HR-TEM images demonstrated spherical morphology featuring Fe₃O₄ functionalised with L-Carnitine, with a range of 13.7 ± 4.55 nm and 13.57 ± 4.16 nm, respectively. TGA indicated thermal stability and inferred the presence of organic content, supporting effective surface modification. VSM analysis confirmed a superparamagnetic nature with decreased magnetic saturation due to the LC coating. The prepared nanocomposite was examined for anti-bacterial activity, and the LC@Fe₃O₄ nanocomposite showed strong antibacterial activity against both gram-positive and gram-negative bacterial strains. Cytotoxicity assays on MDA-MB-231 cells confirmed excellent anti-cancer properties.

Graphical Abstract