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<p>Farnesol shows various pharmacological effects and significant therapeutic potential, but its clinical use is limited due to high volatility and poor solubility. To overcome these issues, we synthesized farnesol-loaded silver nanoparticles (AgNPs) through a chemical reduction method. The nanoparticles exhibited absorption peaks between 399 and 414&#xa0;nm, as determined by UV–visible spectroscopy. The Fourier-transform infrared (FTIR) spectroscopy confirmed the attachment of farnesol to the AgNPs. Drug release studies in phosphate-buffered saline indicated maximum release at pH 5.5. Transmission electron microscopy revealed that the nanoparticles were spherical. In vitro, farnesol-loaded AgNPs exhibited significantly stronger cytotoxicity against breast and colon cancer cells, at least five times greater than AgNPs alone. The IC₅₀ values for HCT116 cells were 7&#xa0;µg/mL and 5&#xa0;µg/mL after 24 and 48&#xa0;h, respectively, while for MCF7 cells, the IC₅₀ was 6&#xa0;µg/mL (24&#xa0;h) and 4.1&#xa0;µg/mL (48&#xa0;h). Colony formation and wound-healing assays further confirmed that loading farnesol onto silver nanoparticles greatly enhanced its anticancer effects.</p>

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Farnesol-loaded Silver Nanoparticles as a Potent Nanotherapeutic Agent Against Colon and Breast Cancer

  • 期刊论文

  • 发表日期：

    2026年3月17日

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  • Tabasum Ali,
  • Ifat Jan,
  • Rabiah Bashir,
  • Zahida Shah,
  • Shabnam Kawoosa,
  • Sheeba Nazir,
  • Khurshid Iqbal Andrabi,
  • Ghulam Nabi Bader

摘要

Farnesol shows various pharmacological effects and significant therapeutic potential, but its clinical use is limited due to high volatility and poor solubility. To overcome these issues, we synthesized farnesol-loaded silver nanoparticles (AgNPs) through a chemical reduction method. The nanoparticles exhibited absorption peaks between 399 and 414 nm, as determined by UV–visible spectroscopy. The Fourier-transform infrared (FTIR) spectroscopy confirmed the attachment of farnesol to the AgNPs. Drug release studies in phosphate-buffered saline indicated maximum release at pH 5.5. Transmission electron microscopy revealed that the nanoparticles were spherical. In vitro, farnesol-loaded AgNPs exhibited significantly stronger cytotoxicity against breast and colon cancer cells, at least five times greater than AgNPs alone. The IC₅₀ values for HCT116 cells were 7 µg/mL and 5 µg/mL after 24 and 48 h, respectively, while for MCF7 cells, the IC₅₀ was 6 µg/mL (24 h) and 4.1 µg/mL (48 h). Colony formation and wound-healing assays further confirmed that loading farnesol onto silver nanoparticles greatly enhanced its anticancer effects.