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<p>Sesamol (SES) exhibits a range of biological activities, including antioxidant, anticancer, cardiovascular, and antihypertensive effects; however, its application in the food industry is limited by its low environmental stability. Accordingly, this study aimed to optimize the formulation of sesamol-loaded nanoparticles composed of soybean protein isolate (SPI), inulin (IN), and xanthan (XAN) nanocomplexes. Particle size, zeta potential, Fourier-transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and in vitro simulated digestion of SES/SPI/IN/XAN nanoparticles were evaluated. In addition, the bioaccessibility of sesamol in simulated gastrointestinal digestion media was investigated. Maximum encapsulation efficiency (88.48%) of SPI/IN/XAN nanoparticles was achieved using 10&#xa0;mg/mL SPI, 5&#xa0;mg/mL IN, and 0.5&#xa0;mg/mL XAN. The average particle size, polydispersity index (PDI), and zeta potential of SPI/IN/XAN nanoparticles were 171.20&#xa0;nm, 0.173, and − 17.35 mV, respectively. Based on differential scanning calorimetry (DSC) results, the SPI/IN/XAN nanoparticle illustrated an endothermic peak at 164.65&#xa0;°C. A controlled release of SES from SPI/IN/XAN nanoparticles has been observed in the digestive system. The bioaccessibility of SES reached 39.75% in SGF and 77.14% in SIF, demonstrating gastric protection and controlled intestinal release via pH-responsive matrix disassembly.</p>

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Formation and Characterization of Sesamol Nanoparticle Loaded by Soy Protein Isolates/Inulin/Xanthan

  • 期刊论文

  • 发表日期：

    2026年3月4日

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  • Elham Naghdipour,
  • Leila Lakzadeh,
  • Mehrnoosh Tadayoni,
  • Maryam Jafari

摘要

Sesamol (SES) exhibits a range of biological activities, including antioxidant, anticancer, cardiovascular, and antihypertensive effects; however, its application in the food industry is limited by its low environmental stability. Accordingly, this study aimed to optimize the formulation of sesamol-loaded nanoparticles composed of soybean protein isolate (SPI), inulin (IN), and xanthan (XAN) nanocomplexes. Particle size, zeta potential, Fourier-transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and in vitro simulated digestion of SES/SPI/IN/XAN nanoparticles were evaluated. In addition, the bioaccessibility of sesamol in simulated gastrointestinal digestion media was investigated. Maximum encapsulation efficiency (88.48%) of SPI/IN/XAN nanoparticles was achieved using 10 mg/mL SPI, 5 mg/mL IN, and 0.5 mg/mL XAN. The average particle size, polydispersity index (PDI), and zeta potential of SPI/IN/XAN nanoparticles were 171.20 nm, 0.173, and − 17.35 mV, respectively. Based on differential scanning calorimetry (DSC) results, the SPI/IN/XAN nanoparticle illustrated an endothermic peak at 164.65 °C. A controlled release of SES from SPI/IN/XAN nanoparticles has been observed in the digestive system. The bioaccessibility of SES reached 39.75% in SGF and 77.14% in SIF, demonstrating gastric protection and controlled intestinal release via pH-responsive matrix disassembly.