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<p>Cu-BTC metal-organic frameworks were created using a solvothermal method at different molar ratios (3:2, 4:2, and 5:2). Highly crystalline octahedral structures with uniform Cu, C, and O distribution were found during characterization, confirming intact organic linkers and well-coordinated metal nodes. A very microporous framework with a BET surface area of 0.5364&#xa0;cc/g was validated by N₂ adsorption, and thermogravimetric measurement revealed an initial weight loss at 173 ° C due to trapped solvents. The substance demonstrated substantial antioxidant activity (DPPH IC <sub>50</sub> = 35.24&#xa0;µg/mL), a positive surface charge (+ 3.5 mV), and good antibacterial activity against <i>S. aureus</i>,<i> E. coli</i>,<i> Candida albicans</i>,<i> and A. flavus.</i> With ROS-mediated oxidative stress (~ 3.5-fold fluorescence increase) as the anticancer mechanism, selective cytotoxicity was seen against A549 lung cancer cells (IC <sub>50</sub> = 10.37&#xa0;µg/mL) while maintaining normal L929 fibroblasts (&gt; 90% viability). All things considered, Cu-BTC (3:2) is a highly porous, structurally homogeneous, and adaptable nanoplatform with encouraging prospects for lung cancer treatment, meriting additional in vivo and mechanistic research.</p> Graphical Abstract <p></p>

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Unveiling Dual-Functionality of Cu-BTC Metal Organic Framework HKUST-1: Structural Characterization and Biomedical Applications

  • 期刊论文

  • 发表日期：

    2026年2月16日

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  • Priyanka Ragupathy,
  • Antalin Casmie Amalraj,
  • Pacha gounder Sakthivel,
  • Vijaya Parthasarathy

摘要

Cu-BTC metal-organic frameworks were created using a solvothermal method at different molar ratios (3:2, 4:2, and 5:2). Highly crystalline octahedral structures with uniform Cu, C, and O distribution were found during characterization, confirming intact organic linkers and well-coordinated metal nodes. A very microporous framework with a BET surface area of 0.5364 cc/g was validated by N₂ adsorption, and thermogravimetric measurement revealed an initial weight loss at 173 ° C due to trapped solvents. The substance demonstrated substantial antioxidant activity (DPPH IC 50 = 35.24 µg/mL), a positive surface charge (+ 3.5 mV), and good antibacterial activity against S. aureus, E. coli, Candida albicans, and A. flavus. With ROS-mediated oxidative stress (~ 3.5-fold fluorescence increase) as the anticancer mechanism, selective cytotoxicity was seen against A549 lung cancer cells (IC 50 = 10.37 µg/mL) while maintaining normal L929 fibroblasts (> 90% viability). All things considered, Cu-BTC (3:2) is a highly porous, structurally homogeneous, and adaptable nanoplatform with encouraging prospects for lung cancer treatment, meriting additional in vivo and mechanistic research.

Graphical Abstract