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<p>Pathogenic bacteria such as <i>Staphylococcus aureus</i> (<i>S. aureus</i>) represent a serious global health concern by forming biofilms that enhance bacterial resistance and persistence in host and environmental niches. Natural compounds such as α-mangostin (α-m) exhibit promising antibacterial potential but low solubility, instability and limited bioavailability restrict their biomedical application. This study prepared α-mangostin-loaded casein–chitosan nanoparticles (α-m NPs) via ionic crosslinking–emulsification under neutral pH conditions and characterized them using dynamic light scattering, scanning electron microscopy, and Fourier-transform infrared spectroscopy, which confirmed efficient encapsulation and structural stability. The results showed that α-m NPs achieved sustained drug release over 72&#xa0;h and exhibited significantly enhanced bacteriostatic and bactericidal effects. Biofilm assays further revealed that α-m NPs more effectively suppressed extracellular polysaccharide secretion and biofilm formation in MRSA T144 and ATCC 29213 strains. These findings as a whole validate α-m NPs as an efficient antibacterial and anti-biofilm nanosystem and establish a polysaccharide–protein nanoplatform with considerable potential for applications in nanomedicine and anti-infective therapy.</p> Graphical abstract <p></p>

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Food-Derived Chitosan–Casein Nanocarriers Enhance the Antibacterial and Anti-biofilm Activities of α-Mangostin

  • 期刊论文

  • 发表日期：

    2026年1月16日

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  • Yifei He,
  • Zhe Wang

摘要

Pathogenic bacteria such as Staphylococcus aureus (S. aureus) represent a serious global health concern by forming biofilms that enhance bacterial resistance and persistence in host and environmental niches. Natural compounds such as α-mangostin (α-m) exhibit promising antibacterial potential but low solubility, instability and limited bioavailability restrict their biomedical application. This study prepared α-mangostin-loaded casein–chitosan nanoparticles (α-m NPs) via ionic crosslinking–emulsification under neutral pH conditions and characterized them using dynamic light scattering, scanning electron microscopy, and Fourier-transform infrared spectroscopy, which confirmed efficient encapsulation and structural stability. The results showed that α-m NPs achieved sustained drug release over 72 h and exhibited significantly enhanced bacteriostatic and bactericidal effects. Biofilm assays further revealed that α-m NPs more effectively suppressed extracellular polysaccharide secretion and biofilm formation in MRSA T144 and ATCC 29213 strains. These findings as a whole validate α-m NPs as an efficient antibacterial and anti-biofilm nanosystem and establish a polysaccharide–protein nanoplatform with considerable potential for applications in nanomedicine and anti-infective therapy.

Graphical abstract