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<p>This study reports the development and evaluation of an Aloe vera-based herbal hair gel enriched with biogenic silver nanoparticles (AgNPs) for enhanced scalp care and therapeutic benefits. The formulation was assessed for structural, physicochemical, and biological properties. Optical microscopy revealed a stable gel matrix with smooth morphology, while physicochemical evaluations confirmed transparency, homogeneity, absence of lumps, optimal viscosity (5.2 cP), spreadability (166.67&#xa0;g·cm/s), and skin-friendly pH (6.92), ensuring suitability for topical application. AgNPs infused hairgel was characterized using DLS, zeta potential and FTIR, confirming nanoparticle formation and stability (zeta potential: − 27.54 mV; average size: 776.9&#xa0;nm; PDI: 0.358). FTIR showed characteristic peaks at 594&#xa0;cm further validated synthesis. Biological assays revealed strong antimicrobial activity against <i>E. coli</i> (12&#xa0;mm) and <i>Candida albicans</i> (11&#xa0;mm) at 100&#xa0;µg/mL. Antioxidant evaluation demonstrated significant DPPH (34.79–80.45%) and ABTS (44.93–72.8%) scavenging activity, comparable to standard antioxidants. Cytotoxicity assessment against 3T3 mouse fibroblast cell lines confirmed bio-safety at concentrations up to 150&#xa0;µg/mL. Overall, the Aloe vera–AgNP gel exhibits multifunctional properties, positioning it as a promising natural formulation for scalp health management and infection control.</p> Graphical Abstract <p></p>

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Innovative Aloe Vera Gel Formulation Containing Biogenic Silver Nanoparticles for Enhanced Scalp Health and Antimicrobial Activity

  • 期刊论文

  • 发表日期：

    2026年1月16日

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  • Kaviya Maran,
  • Tanmoy Das,
  • Pooja Mittal,
  • Tanima Bhattacharya

摘要

This study reports the development and evaluation of an Aloe vera-based herbal hair gel enriched with biogenic silver nanoparticles (AgNPs) for enhanced scalp care and therapeutic benefits. The formulation was assessed for structural, physicochemical, and biological properties. Optical microscopy revealed a stable gel matrix with smooth morphology, while physicochemical evaluations confirmed transparency, homogeneity, absence of lumps, optimal viscosity (5.2 cP), spreadability (166.67 g·cm/s), and skin-friendly pH (6.92), ensuring suitability for topical application. AgNPs infused hairgel was characterized using DLS, zeta potential and FTIR, confirming nanoparticle formation and stability (zeta potential: − 27.54 mV; average size: 776.9 nm; PDI: 0.358). FTIR showed characteristic peaks at 594 cm further validated synthesis. Biological assays revealed strong antimicrobial activity against E. coli (12 mm) and Candida albicans (11 mm) at 100 µg/mL. Antioxidant evaluation demonstrated significant DPPH (34.79–80.45%) and ABTS (44.93–72.8%) scavenging activity, comparable to standard antioxidants. Cytotoxicity assessment against 3T3 mouse fibroblast cell lines confirmed bio-safety at concentrations up to 150 µg/mL. Overall, the Aloe vera–AgNP gel exhibits multifunctional properties, positioning it as a promising natural formulation for scalp health management and infection control.

Graphical Abstract