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<p>This study details the development and characterization of Chitosan (CS)/ Xanthan gum (XG) hydrogel loaded with Corallina officinalis polysaccharides (COP). The hydrogel was prepared using a 4:1 ratio of XG to CS, followed by COP loading through the diffusion and adsorption method. Characterization involved evaluating morphology, structure, porosity, biocompatibility, biodegradability, stability, and biological activities. The hydrogel achieved a high encapsulation efficiency of 79.20 ± 2.80% and a drug loading capacity of 91.40 ± 1.50%. Scanning electron microscopy (SEM) revealed a cross-linked structure with 68.53 ± 2.66% porosity and an average pore size of 29.33 ± 1.77&#xa0;μm. Dynamic light scattering (DLS) confirmed the presence of nanoscale self-assembled polyelectrolyte complexes within the hydrogel, with a hydrodynamic particle size of 4.19 ± 0.41&#xa0;nm and a zeta potential of − 34.40 ± 4.96 mV. Fourier Transform Infrared (FT-IR) analysis confirmed the presence of strong interactions within the hydrogel components. The hydrogel enabled sustained COP release over 7&#xa0;h, reaching 75.82 ± 0.99%. It showed minimal degradation over 15 days, a high swelling index, excellent water retention, and physical stability with a low permeability rate of 0.89 ± 0.14. The enhanced antioxidant and anti-inflammatory activities of COP within the hydrogel suggest its potential for controlled drug delivery and tissue engineering applications.</p> Graphical Abstract <p>Schematic representation of the formulation and evaluation of chitosan/xanthan gum (CS/XG) hydrogel loaded with <i>Corallina officinalis </i>polysaccharides (COP)<i>.</i></p> <p></p>

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Marine-Derived Polysaccharide-Loaded Chitosan/Xanthan Gum Hydrogel: Development, Characterization, and Biocompatibility Assessment

  • 期刊论文

  • 发表日期：

    2026年1月16日

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  • Marwa Ahmed Abdelfattah,
  • Ayman Saber Mohamed,
  • Sohair R. Fahmy,
  • Shimaa A. Sadek

摘要

This study details the development and characterization of Chitosan (CS)/ Xanthan gum (XG) hydrogel loaded with Corallina officinalis polysaccharides (COP). The hydrogel was prepared using a 4:1 ratio of XG to CS, followed by COP loading through the diffusion and adsorption method. Characterization involved evaluating morphology, structure, porosity, biocompatibility, biodegradability, stability, and biological activities. The hydrogel achieved a high encapsulation efficiency of 79.20 ± 2.80% and a drug loading capacity of 91.40 ± 1.50%. Scanning electron microscopy (SEM) revealed a cross-linked structure with 68.53 ± 2.66% porosity and an average pore size of 29.33 ± 1.77 μm. Dynamic light scattering (DLS) confirmed the presence of nanoscale self-assembled polyelectrolyte complexes within the hydrogel, with a hydrodynamic particle size of 4.19 ± 0.41 nm and a zeta potential of − 34.40 ± 4.96 mV. Fourier Transform Infrared (FT-IR) analysis confirmed the presence of strong interactions within the hydrogel components. The hydrogel enabled sustained COP release over 7 h, reaching 75.82 ± 0.99%. It showed minimal degradation over 15 days, a high swelling index, excellent water retention, and physical stability with a low permeability rate of 0.89 ± 0.14. The enhanced antioxidant and anti-inflammatory activities of COP within the hydrogel suggest its potential for controlled drug delivery and tissue engineering applications.

Graphical Abstract

Schematic representation of the formulation and evaluation of chitosan/xanthan gum (CS/XG) hydrogel loaded with Corallina officinalis polysaccharides (COP).