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<p>Herein, we developed rutin loaded nanostructured lipid carriers (RUTNLCs) incorporated hydrogel for the effective treatment of psoriasis. RUTNLCs were prepared using the high-pressure micro fluidization technique and optimized employing a Box-Behnken Design, considering three independent variables: solid lipid: liquid lipid ratio (X1), surfactant concentration (X2), and number of micro fluidization cycles (X3), each at three levels. Glyceryl monostearate (GMS), Oleic acid, and Tween 80 were selected as the solid lipid, liquid lipid, and surfactant respectively, based on solubility studies. The optimized formulation showed an average particle size of 66.4 ± 2.45&#xa0;nm, zeta potential of − 30 mV, and entrapment efficiency of 90.2 ± 5.62%. Structural and functional analysis confirmed no interaction between rutin and formulation excipients. Thermal and X-ray diffraction results indicated successful incorporation of rutin into the lipid matrix, while SEM imaging revealed spherical morphology of the RUTNLCs. The optimised formulation showed 76.25 ± 3.05% drug released over 12&#xa0;h, following Higuchi kinetic. Additionally, the optimized RUTNLCs were further incorporated into a Carbopol 934 based hydrogel (RUTNLCG) and assessed for drug release, skin irritation, and anti-psoriatic efficacy. The hydrogel demonstrated enhanced drug permeation (71.27 ± 1.20%) with superior transdermal flux (1.496&#xa0;µg/cm²/min) and permeability coefficient (0.748&#xa0;cm/min), compared to pure rutin incorporated hydrogel. Further, skin irritation studies confirmed dermal compatibility. Furthermore, in vivo study, evaluated using a rat tail model, demonstrated superior anti-psoriatic efficacy with increased orthokeratosis and therapeutic response, compared to a marketed formulation. Thus, the rutin loaded NLCs based hydrogel represents a promising herbal based transdermal potential for psoriasis management.</p> Graphical Abstract <p></p>

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Rutin-Loaded Nanostructured Lipid Carriers incorporated Hydrogel for the Management Psoriasis: In Vitro and In Vivo Assessment

  • 期刊论文

  • 发表日期：

    2025年12月22日

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  • Puja B. Pujari,
  • Anilkumar J. Shinde,
  • Abhijeet C. Shedmake,
  • Anbhule Sachin Jalindar,
  • Sachin S. Mali,
  • Sudarshan Singh

摘要

Herein, we developed rutin loaded nanostructured lipid carriers (RUTNLCs) incorporated hydrogel for the effective treatment of psoriasis. RUTNLCs were prepared using the high-pressure micro fluidization technique and optimized employing a Box-Behnken Design, considering three independent variables: solid lipid: liquid lipid ratio (X1), surfactant concentration (X2), and number of micro fluidization cycles (X3), each at three levels. Glyceryl monostearate (GMS), Oleic acid, and Tween 80 were selected as the solid lipid, liquid lipid, and surfactant respectively, based on solubility studies. The optimized formulation showed an average particle size of 66.4 ± 2.45 nm, zeta potential of − 30 mV, and entrapment efficiency of 90.2 ± 5.62%. Structural and functional analysis confirmed no interaction between rutin and formulation excipients. Thermal and X-ray diffraction results indicated successful incorporation of rutin into the lipid matrix, while SEM imaging revealed spherical morphology of the RUTNLCs. The optimised formulation showed 76.25 ± 3.05% drug released over 12 h, following Higuchi kinetic. Additionally, the optimized RUTNLCs were further incorporated into a Carbopol 934 based hydrogel (RUTNLCG) and assessed for drug release, skin irritation, and anti-psoriatic efficacy. The hydrogel demonstrated enhanced drug permeation (71.27 ± 1.20%) with superior transdermal flux (1.496 µg/cm²/min) and permeability coefficient (0.748 cm/min), compared to pure rutin incorporated hydrogel. Further, skin irritation studies confirmed dermal compatibility. Furthermore, in vivo study, evaluated using a rat tail model, demonstrated superior anti-psoriatic efficacy with increased orthokeratosis and therapeutic response, compared to a marketed formulation. Thus, the rutin loaded NLCs based hydrogel represents a promising herbal based transdermal potential for psoriasis management.

Graphical Abstract