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<p>Co<sub>3</sub>O<sub>4</sub> nanoparticles (NPs) have demonstrated broad applicability across various biomedical and industrial domains. Among synthesis approaches, green synthesis methods are increasingly favored over conventional techniques because of their cost-effectiveness, eco-friendliness, and reduced toxicity. In the present study, cobalt chloride was used as the precursor, and the fungus <i>Rhizoctonia solani</i> facilitated the biosynthesis of Co₃O₄ NPs. The NPs were thoroughly characterized using Fourier-transform infrared spectroscopy (FTIR) analysis reveal presence of Co-O, C = O, C-O, and C-C functional group in synthesize Co₃O₄ NPs, transmission electron microscopy (TEM) shown an average particle size of approximately 5.57&#xa0;nm while X-ray diffraction (XRD) studies showed the average size of the crystal of about 5.41&#xa0;nm (JCPDS-42-1467), scanning electron microscopy (SEM) shown irregular polyhedral shape with a relatively narrow size distribution and energy dispersive spectroscopy (EDS) which revealed the atomic percentages of Co is 69.05% and for O is 21.82%. The antibacterial potential of the fabricated Co₃O₄ NPs was assessed compared to both Gram-negative and Gram-positive bacterial species namely <i>Streptococcus agalactiae</i>, <i>Staphylococcus saprophyticus</i>, <i>Staphylococcus aureus</i>,<i> Escherichia coli</i>, and <i>Pseudomonas aeruginosa</i>, at 100&#xa0;µg/mL of concentration. Where, highest zone of inhibition was observed against gram-positive bacteria (<i>Streptococcus agalactiae =</i> 18 ± 0.47&#xa0;mm) as compared to gram negative bacteria. The MTT assay was carried out for&#xa0;Co<sub>3</sub>O<sub>4</sub> NPs against Human lung adenocarcinoma A549 cells which shown potential effect on these cells. Furthermore, their, anti-inflammatory, anticancer, anti-diabetic and antioxidant potentials were systematically investigated to explore their potential biomedical applications.</p> Graphical Abstract <p></p>

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Rhizoctonia Solani Mediated Myco-synthesis of Co3O4 NPs and Its Characterization for Biological Activity Evaluation: Antibacterial, Anticancer, Anti-inflammatory, and Antidiabetic Effects

  • 期刊论文

  • 发表日期：

    2025年12月17日

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  • Tarkeshwari A. Madavi,
  • Sachin T. Yerpude,
  • Aafreen Firdaus,
  • Kumud R. Gajhbhiye,
  • Qudsiya Sana Md. Qamruzzama Sheikh,
  • Pavan R. Bhilkar,
  • Ratiram G. Chaudhary,
  • Alok R. Rai

摘要

Co3O4 nanoparticles (NPs) have demonstrated broad applicability across various biomedical and industrial domains. Among synthesis approaches, green synthesis methods are increasingly favored over conventional techniques because of their cost-effectiveness, eco-friendliness, and reduced toxicity. In the present study, cobalt chloride was used as the precursor, and the fungus Rhizoctonia solani facilitated the biosynthesis of Co₃O₄ NPs. The NPs were thoroughly characterized using Fourier-transform infrared spectroscopy (FTIR) analysis reveal presence of Co-O, C = O, C-O, and C-C functional group in synthesize Co₃O₄ NPs, transmission electron microscopy (TEM) shown an average particle size of approximately 5.57 nm while X-ray diffraction (XRD) studies showed the average size of the crystal of about 5.41 nm (JCPDS-42-1467), scanning electron microscopy (SEM) shown irregular polyhedral shape with a relatively narrow size distribution and energy dispersive spectroscopy (EDS) which revealed the atomic percentages of Co is 69.05% and for O is 21.82%. The antibacterial potential of the fabricated Co₃O₄ NPs was assessed compared to both Gram-negative and Gram-positive bacterial species namely Streptococcus agalactiae, Staphylococcus saprophyticus, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, at 100 µg/mL of concentration. Where, highest zone of inhibition was observed against gram-positive bacteria (Streptococcus agalactiae = 18 ± 0.47 mm) as compared to gram negative bacteria. The MTT assay was carried out for Co3O4 NPs against Human lung adenocarcinoma A549 cells which shown potential effect on these cells. Furthermore, their, anti-inflammatory, anticancer, anti-diabetic and antioxidant potentials were systematically investigated to explore their potential biomedical applications.

Graphical Abstract