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<p><i>Curcuma caesia</i>, known for its antibacterial properties, is being focused and has gained major interest in research. Silver nanoparticles (AgNPs) have gained worldwide recognition for exhibiting various properties and their applications in multiple fields. AgNPs have a greater extent of antibacterial capacity in both Gram-positive and Gram-negative bacteria, which also include multidrug-resistant bacteria. This paper solely focuses on synthesis of silver nanoparticles mediated by <i>C. caesia</i> (CcAgNPs), and their antibacterial properties in multidrug-resistant pathogens involved in cellulitis and skin infection. The synthesized nanoparticles were primarily confirmed with the Surface Plasma Resonance peak, which was observed at 420&#xa0;nm. The particles were found as polymorphic under a magnification of 200&#xa0;nm from FESEM. The particles size was confirmed as 200&#xa0;nm from DLS, which carries a charge of -15.9 mV indicating its stability. Skin infection is still a burden in the healthcare sector, and the CcAgNPs are tested and evaluated for their efficiency against cellulitis causing Gram-negative bacteria. The strains chosen for this study are three different strains of <i>Escherichia coli</i>, namely EC ATCC, EC 53T, EC 11B, along with three different strains of <i>Klebsiella pneumoniae</i>, namely KP ATCC, KP 5B and KP 48 T. The antibacterial properties of the CcAgNPs are explored by performing the MIC, MBC, followed by a biofilm assay. Furthermore, to discuss its mechanism of action, an array of biochemical assays was performed which reveals its effect on membrane integrity and the antioxidant system. Following this result, the CcAgNPs were formulated as a nanocream and tested for its efficiency. The results revealed that the synthesized silver nanoparticles have much more potential in treating cellulitis causing pathogens when compared to the standard antibiotic, ampicillin. This research could pave a new profound way and help in the battle against bacterial mediated skin infections and cellulitis. This study aligns with the promotion of science, technology, and innovation globally towards achieving sustainable development goals.</p>

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Biocompatible Silver Nanoparticles to Develop Dermo-cosmetic and Dermatological Products for Cellulitis

  • 期刊论文

  • 发表日期：

    2025年12月17日

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  • S. Jaswanthika,
  • S. Ranjani,
  • S. Hemalatha

摘要

Curcuma caesia, known for its antibacterial properties, is being focused and has gained major interest in research. Silver nanoparticles (AgNPs) have gained worldwide recognition for exhibiting various properties and their applications in multiple fields. AgNPs have a greater extent of antibacterial capacity in both Gram-positive and Gram-negative bacteria, which also include multidrug-resistant bacteria. This paper solely focuses on synthesis of silver nanoparticles mediated by C. caesia (CcAgNPs), and their antibacterial properties in multidrug-resistant pathogens involved in cellulitis and skin infection. The synthesized nanoparticles were primarily confirmed with the Surface Plasma Resonance peak, which was observed at 420 nm. The particles were found as polymorphic under a magnification of 200 nm from FESEM. The particles size was confirmed as 200 nm from DLS, which carries a charge of -15.9 mV indicating its stability. Skin infection is still a burden in the healthcare sector, and the CcAgNPs are tested and evaluated for their efficiency against cellulitis causing Gram-negative bacteria. The strains chosen for this study are three different strains of Escherichia coli, namely EC ATCC, EC 53T, EC 11B, along with three different strains of Klebsiella pneumoniae, namely KP ATCC, KP 5B and KP 48 T. The antibacterial properties of the CcAgNPs are explored by performing the MIC, MBC, followed by a biofilm assay. Furthermore, to discuss its mechanism of action, an array of biochemical assays was performed which reveals its effect on membrane integrity and the antioxidant system. Following this result, the CcAgNPs were formulated as a nanocream and tested for its efficiency. The results revealed that the synthesized silver nanoparticles have much more potential in treating cellulitis causing pathogens when compared to the standard antibiotic, ampicillin. This research could pave a new profound way and help in the battle against bacterial mediated skin infections and cellulitis. This study aligns with the promotion of science, technology, and innovation globally towards achieving sustainable development goals.