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<p>Silver nanostructures are recognized for their antimicrobial, fungicidal, bactericidal, and toxic activity in various organisms. This toxicity can be controlled by size, shape, and coating. Therefore, in this work, the toxicity of bare and EDTA-coated nanorods in rainbow trout was investigated. Successful nanorod formation was demonstrated by transmission electron microscopy, where the rods presented a length-to-width aspect ratio of 3.1. Furthermore, the particles in solution presented an average size of 56.18&#xa0;nm, indicating high stability and the absence of aggregates. Characteristic absorption bands were recorded at 406 and 543&#xa0;nm of the visible spectrum. Using Raman spectroscopy and vibrational bands with EDTA revealed the functionalization of the silver nanoparticles. The EDTA coating was shown to modify the toxic properties of the silver nanoparticles per se. By intraperitoneal injection at an acute dose of 100&#xa0;µg/g of body weight in rainbow trout, the kidney was shown to be the target organ. For the first time, functionalized silver nanoparticles were shown to efficiently degrade reactive oxygen species, an effect attributed to the synergy between the metal nanoparticles and the functionalizing agent. Finally, the silver nanoparticles developed in this work showed that their physicochemical properties vary depending on the coating, and their application could be extended to various areas of research.</p>

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Development of an Antioxidant Agent Based on EDTA-Functionalized Silver Nanorods

  • 期刊论文

  • 发表日期：

    2025年10月27日

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  • Guillermo Iván Jiménez-Flores,
  • Miguel Ángel Méndez-Rojas,
  • Cuauhtémoc Morales-Cruz,
  • Maribel Méndez-Tepepa,
  • Edelmira García-Nieto,
  • Libertad Juárez-Santacruz,
  • Angel Netzahual-Lopantzi

摘要

Silver nanostructures are recognized for their antimicrobial, fungicidal, bactericidal, and toxic activity in various organisms. This toxicity can be controlled by size, shape, and coating. Therefore, in this work, the toxicity of bare and EDTA-coated nanorods in rainbow trout was investigated. Successful nanorod formation was demonstrated by transmission electron microscopy, where the rods presented a length-to-width aspect ratio of 3.1. Furthermore, the particles in solution presented an average size of 56.18 nm, indicating high stability and the absence of aggregates. Characteristic absorption bands were recorded at 406 and 543 nm of the visible spectrum. Using Raman spectroscopy and vibrational bands with EDTA revealed the functionalization of the silver nanoparticles. The EDTA coating was shown to modify the toxic properties of the silver nanoparticles per se. By intraperitoneal injection at an acute dose of 100 µg/g of body weight in rainbow trout, the kidney was shown to be the target organ. For the first time, functionalized silver nanoparticles were shown to efficiently degrade reactive oxygen species, an effect attributed to the synergy between the metal nanoparticles and the functionalizing agent. Finally, the silver nanoparticles developed in this work showed that their physicochemical properties vary depending on the coating, and their application could be extended to various areas of research.