Scholarlink

<p>Skin aging, driven by factors such as decreased collagen and elastin levels, cellular senescence, and environmental stressors, necessitates the development of innovative and effective antiaging strategies.&#xa0;In this study, a novel curcumin/hyaluronic acid nanoformulation (NCur/HA) was synthesized and evaluated in vitro and in vivo for its potential as a skin antiaging treatment. Curcumin nanoparticles were prepared via nanoprecipitation in the presence of hyaluronic acid (HA) and subsequently incorporated into a carbomer-based gel for topical application.&#xa0;Dynamic light scattering (DLS) analysis revealed nanoparticles with an Z-average diameter of 48&#xa0;nm and a zeta potential of -3.25 mV. Field emission scanning electron microscopy (FE-SEM) confirmed the narrow size distribution and spherical morphology of NCur/HA. Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analyses confirmed the successful incorporation of curcumin and HA into the nanoformulation, with the crystalline structure of curcumin transitioning to an amorphous state. The MTT assay showed that NCur/HA had no cytotoxic effect on the L929 cell line, and OECD 404 tests confirmed the absence of skin irritation in rabbit models. Furthermore, the topical application of the NCur/HA gel to rat skin exhibited promising antiaging effects. Histopathological analysis showed that pretreatment with NCur/HA was associated with improved conditions, as no signs of necrosis were observed in this group. These findings highlight the potential of NCur/HA as a safe and effective nanoformulation for preventing skin aging induced by UVB exposure.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Preparation and Skin Antiaging Effects of Nanocurcumin/hyaluronic Acid Hydrogels in a Rat Model

  • 期刊论文

  • 发表日期：

    2025年12月17日

查看全文
  • Mahsa Khosravi,
  • Hamed Tabasi,
  • Sadegh Shirian,
  • Mahdi Nasiri,
  • Mahmoud Osanloo,
  • Hiva Alipanah,
  • Esmaeil Mirzaei

摘要

Skin aging, driven by factors such as decreased collagen and elastin levels, cellular senescence, and environmental stressors, necessitates the development of innovative and effective antiaging strategies. In this study, a novel curcumin/hyaluronic acid nanoformulation (NCur/HA) was synthesized and evaluated in vitro and in vivo for its potential as a skin antiaging treatment. Curcumin nanoparticles were prepared via nanoprecipitation in the presence of hyaluronic acid (HA) and subsequently incorporated into a carbomer-based gel for topical application. Dynamic light scattering (DLS) analysis revealed nanoparticles with an Z-average diameter of 48 nm and a zeta potential of -3.25 mV. Field emission scanning electron microscopy (FE-SEM) confirmed the narrow size distribution and spherical morphology of NCur/HA. Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analyses confirmed the successful incorporation of curcumin and HA into the nanoformulation, with the crystalline structure of curcumin transitioning to an amorphous state. The MTT assay showed that NCur/HA had no cytotoxic effect on the L929 cell line, and OECD 404 tests confirmed the absence of skin irritation in rabbit models. Furthermore, the topical application of the NCur/HA gel to rat skin exhibited promising antiaging effects. Histopathological analysis showed that pretreatment with NCur/HA was associated with improved conditions, as no signs of necrosis were observed in this group. These findings highlight the potential of NCur/HA as a safe and effective nanoformulation for preventing skin aging induced by UVB exposure.