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<p>This study reports the green synthesis of silver nanoparticles (AgNPs) using the cell-free filtrate (CFF) of the marine-derived fungus <i>Aspergillus caespitosus</i>, with an emphasis on their multifunctional biological activities. AgNPs were synthesized using fungal CFF and characterized by UV–Vis spectroscopy, ATR-FTIR, X-ray diffraction (XRD), and high-resolution transmission electron microscopy (HR-TEM). Biological evaluations included antimicrobial assays, DPPH antioxidant tests, larvicidal bioassays, and MTT-based cytotoxicity analysis against MCF-7 cells. UV–Vis analysis showed an SPR peak at 437&#xa0;nm, while XRD and HR-TEM confirmed crystalline, spherical nanoparticles averaging 6.93 ± 1.42&#xa0;nm. The AgNPs exhibited potent antimicrobial activity, strong antioxidant effects (IC<sub>50:</sub> 56.34&#xa0;μg/mL), significant larvicidal activity (<i>Culex quinquefasciatus</i> LC<sub>50</sub>: 45.50&#xa0;µg/mL; <i>Aedes aegypti</i> LC<sub>50</sub>: 59.70&#xa0;µg/mL), and cytotoxicity against MCF-7 cells (IC<sub>50</sub>: 48.92 ± 2.17&#xa0;µg/mL). This is the first report on the biogenic synthesis of AgNPs using marine <i>A</i>. <i>caespitosus</i>, revealing their potential as eco-friendly agents for antimicrobial, larvicidal, and anticancer applications.</p> Graphical Abstract <p></p>

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Marine-Derived Aspergillus caespitosus-Mediated Silver Nanoparticle Synthesis: Characterization and Evaluation of Bioactivities

  • 期刊论文

  • 发表日期：

    2025年12月9日

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  • Harsh Mistry,
  • Rashmi Thakor,
  • Nilam Parmar,
  • Krupali Trivedi,
  • Devendrasinh Jhala,
  • Gulomov Gafurjon Shavkatbek Ugli,
  • Sherzodbek Tashbaev,
  • Dipak Kumar Sahoo,
  • Ashish Patel,
  • Himanshu Bariya

摘要

This study reports the green synthesis of silver nanoparticles (AgNPs) using the cell-free filtrate (CFF) of the marine-derived fungus Aspergillus caespitosus, with an emphasis on their multifunctional biological activities. AgNPs were synthesized using fungal CFF and characterized by UV–Vis spectroscopy, ATR-FTIR, X-ray diffraction (XRD), and high-resolution transmission electron microscopy (HR-TEM). Biological evaluations included antimicrobial assays, DPPH antioxidant tests, larvicidal bioassays, and MTT-based cytotoxicity analysis against MCF-7 cells. UV–Vis analysis showed an SPR peak at 437 nm, while XRD and HR-TEM confirmed crystalline, spherical nanoparticles averaging 6.93 ± 1.42 nm. The AgNPs exhibited potent antimicrobial activity, strong antioxidant effects (IC50: 56.34 μg/mL), significant larvicidal activity (Culex quinquefasciatus LC50: 45.50 µg/mL; Aedes aegypti LC50: 59.70 µg/mL), and cytotoxicity against MCF-7 cells (IC50: 48.92 ± 2.17 µg/mL). This is the first report on the biogenic synthesis of AgNPs using marine A. caespitosus, revealing their potential as eco-friendly agents for antimicrobial, larvicidal, and anticancer applications.

Graphical Abstract