Aim <p>Onychomycosis treatment faces challenges due to limitations of conventional antifungal formulations, including poor drug solubility and penetration. This study aimed to overcome these by developing a pluronic micelles-based gel for Econazole nitrate. The main objective of this article was to investigate the importance of pluronic micelles-based gel in overcoming the limitations of the conventional formulation of Econazole nitrate.</p> Method <p>The pluronic polymers self-assemble over critical micelle concentration and form micelles that help to enhance the solubility of the drug. The optimal micellar formulation was chosen based on the lowest micelle size (116.9&#xa0;nm), highest entrapment efficiency (85.23% ± 1.73%), and drug loading (82.31%) of Econazole nitrate-loaded polymeric micelles made using the thin film hydration&#xa0;method. After characterizing Econazole nitrate-loaded polymeric micelles made using the rotary evaporation process, the best micellar formulation was chosen. The optimized formulation&#xa0;was formulated&#xa0;as a gel and evaluated based on several standards.</p> Result <p>The formulated micelles-based gel exhibited excellent and enhanced permeation compared to conventional gel. The gel fitted the Korsmeyer–Peppas model with an <i>R</i>² value of 0.9765. The pharmacokinetic study showed that the micelles-loaded gel increased the bioavailability, providing a sustained release of the drug.</p> Conclusion <p>Micelles deliver econazole nitrate in a more efficient, targeted, and sustained manner, which leads to successful solubilization.</p>