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<p>Hepatocellular carcinoma (HCC), as a highly lethal malignant tumor, ranks as the sixth most common cancer and the third leading cause of human death worldwide. Traditional treatment methods are limited by toxic side effects and drug resistance. This study focuses on the poorly water-soluble herb release characteristics of multi-layer coaxial nanofibers (NFs) tubes in hepatic artery embolization (TACE). A PVP/PCL core-shell structure was developed for the efficient loading and controlled release of baicalin (BG). The water-soluble PVP core ensured loading, while the compatible PCL shell enabled controlled release. Further sustained-release experiments simulated the treatment process. During in vitro release, the NFs shell showed a stable release rate after 20&#xa0;h. Its cumulative release was 4.3% with a duration exceeding 1500&#xa0;h. In contrast, the nanofiber core (NFC) layer exhibited rapid release and stabilized after 25&#xa0;h. Accurate regulation of the release rate of the poorly water-soluble herb BG can be precisely controlled. This study provides innovative strategies for the treatment of HCC, which are expected to improve treatment efficacy and reduce side effects.</p>

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Baicalin-Loaded Multi-layer Coaxial Nanofiber Tubes for Hepatic Artery Chemoembolization

  • 期刊论文

  • 发表日期：

    2025年10月16日

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  • Ziyang Ding,
  • Shiqi Lei,
  • Chang Zhou,
  • Xinming Wang,
  • Yanling Quan,
  • Zhongliang Jiang,
  • Qingqing Ni,
  • Ke Ma,
  • Wei Chen

摘要

Hepatocellular carcinoma (HCC), as a highly lethal malignant tumor, ranks as the sixth most common cancer and the third leading cause of human death worldwide. Traditional treatment methods are limited by toxic side effects and drug resistance. This study focuses on the poorly water-soluble herb release characteristics of multi-layer coaxial nanofibers (NFs) tubes in hepatic artery embolization (TACE). A PVP/PCL core-shell structure was developed for the efficient loading and controlled release of baicalin (BG). The water-soluble PVP core ensured loading, while the compatible PCL shell enabled controlled release. Further sustained-release experiments simulated the treatment process. During in vitro release, the NFs shell showed a stable release rate after 20 h. Its cumulative release was 4.3% with a duration exceeding 1500 h. In contrast, the nanofiber core (NFC) layer exhibited rapid release and stabilized after 25 h. Accurate regulation of the release rate of the poorly water-soluble herb BG can be precisely controlled. This study provides innovative strategies for the treatment of HCC, which are expected to improve treatment efficacy and reduce side effects.