Scholarlink

<p>Cancer, the leading cause of global mortality, disproportionately affects developing countries, straining healthcare systems. Combination therapies, including photodynamic-photothermal, chemo-photothermal, and chemo-thermal, enhance drug delivery and surpass single therapies in efficacy. Polydopamine (PDA), a melanin-inspired biopolymer, has gained attention for its biocompatibility, ease of modification, strong adhesion, and excellent photothermal properties. These features make PDA an ideal platform for multifunctional nanocarriers in cancer treatment. Integrating PDA-based nanoparticles with stimuli-responsive materials can enhance the drug delivery mechanism, increase treatment precision, and significantly reduce systemic toxicity, thereby ensuring patient safety. This review discusses the latest advancements in PDA-based nanocarriers, focusing on their role in targeted drug delivery, imaging, and therapy for aggressive cancers like lung, breast, colorectal, prostate, and liver cancer, which are major contributors to global cancer-related deaths. The findings underscore the potential of PDA-based nanocarriers and the urgent need for innovative, effective treatment strategies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Polydopamine-Based Nanomaterials For Multifunctional Cancer Therapy

  • 期刊论文

  • 发表日期：

    2025年9月27日

查看全文
  • Anbazhagan Thirumalai,
  • Koyeli Girigoswami,
  • Debosreeta Bose,
  • Agnishwar Girigoswami

摘要

Cancer, the leading cause of global mortality, disproportionately affects developing countries, straining healthcare systems. Combination therapies, including photodynamic-photothermal, chemo-photothermal, and chemo-thermal, enhance drug delivery and surpass single therapies in efficacy. Polydopamine (PDA), a melanin-inspired biopolymer, has gained attention for its biocompatibility, ease of modification, strong adhesion, and excellent photothermal properties. These features make PDA an ideal platform for multifunctional nanocarriers in cancer treatment. Integrating PDA-based nanoparticles with stimuli-responsive materials can enhance the drug delivery mechanism, increase treatment precision, and significantly reduce systemic toxicity, thereby ensuring patient safety. This review discusses the latest advancements in PDA-based nanocarriers, focusing on their role in targeted drug delivery, imaging, and therapy for aggressive cancers like lung, breast, colorectal, prostate, and liver cancer, which are major contributors to global cancer-related deaths. The findings underscore the potential of PDA-based nanocarriers and the urgent need for innovative, effective treatment strategies.