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<p>This study embarked on a fascinating quest to explore the effects of biological coatings on the multifunctional properties of zinc selenium nanoparticles (ZnSe NPs). In this context, ZnSe nanoparticles were synthesized by coating with water-soluble polysaccharides from the seaweed, <i>Ulva fasciata</i> (ulvan), to compare their bioactivity and biocompatibility with PVP-ZnSe NPs. After synthesizing the coated ZnSe NPs, characterization was conducted using various analytical techniques, such as UV–visible spectroscopy, FTIR, SEM–EDX, and TEM. Multiple functions of the as-prepared NPs were investigated, including antimicrobial, antibiofilm, antioxidant, anti-inflammatory, cytotoxicity, LDH release, and cell migration assessments. The UV–Vis spectra of PVP-ZnSe NPs and UL-ZnSe NPs showed distinct peaks at 407 and 411&#xa0;nm, respectively. FTIR analysis provided insight into the functional groups involved in the formation and stability of ZnSe NPs. SEM and TEM images revealed regular and spherical shapes with smooth surfaces and somewhat aggregated particles, with average sizes of 20 and 35&#xa0;nm for PVP-ZnSe NPs and UL-ZnSe NPs, respectively. According to XRD analysis, PVP-ZnSe NPs have a regular crystalline phase, whereas UL-ZnSe NPs exhibited a slightly amorphous nature. The antimicrobial and antibiofilm actions of UL-ZnSe NPs and PVP-ZnSe NPs demonstrated moderate inhibition against <i>S. aureus</i> and <i>P. aeruginosa</i> and potent inhibition against <i>C. albicans</i>. Furthermore, the DPPH radical scavenging assays and in vitro anti-inflammatory assessments indicated that UL-ZnSe NPs exhibited high potency (78.4%). Cytotoxicity assays demonstrated high compatibility of UL-ZnSe NPs with normal human fibroblasts (HF) and less compatibility with epidermal carcinoma of the mouth (KB) cell lines. Although metal nanostructures may have promising therapeutic potential, several factors, such as coating agents, can impart unique physicochemical properties, leading to enhanced performance. Here, the functionalization of NPs with ulvan yielded the best output, which could serve as an alternative for synthesizing metal NPs with high potency and minimal side effects.</p>

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Multifunctional Bioactivity of Zinc Selenide Nanoparticles Coated with Seaweed Polysaccharide from Ulva fasciata

  • 期刊论文

  • 发表日期：

    2025年12月17日

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  • Maryam Karkhane,
  • Seyedeh Zahra Mirzaei,
  • Arian Karimi Rouzbahani,
  • Asma Sepahdar,
  • Suresh Ghotekar,
  • Zeinab Sharafi,
  • Abdolrazagh Marzban

摘要

This study embarked on a fascinating quest to explore the effects of biological coatings on the multifunctional properties of zinc selenium nanoparticles (ZnSe NPs). In this context, ZnSe nanoparticles were synthesized by coating with water-soluble polysaccharides from the seaweed, Ulva fasciata (ulvan), to compare their bioactivity and biocompatibility with PVP-ZnSe NPs. After synthesizing the coated ZnSe NPs, characterization was conducted using various analytical techniques, such as UV–visible spectroscopy, FTIR, SEM–EDX, and TEM. Multiple functions of the as-prepared NPs were investigated, including antimicrobial, antibiofilm, antioxidant, anti-inflammatory, cytotoxicity, LDH release, and cell migration assessments. The UV–Vis spectra of PVP-ZnSe NPs and UL-ZnSe NPs showed distinct peaks at 407 and 411 nm, respectively. FTIR analysis provided insight into the functional groups involved in the formation and stability of ZnSe NPs. SEM and TEM images revealed regular and spherical shapes with smooth surfaces and somewhat aggregated particles, with average sizes of 20 and 35 nm for PVP-ZnSe NPs and UL-ZnSe NPs, respectively. According to XRD analysis, PVP-ZnSe NPs have a regular crystalline phase, whereas UL-ZnSe NPs exhibited a slightly amorphous nature. The antimicrobial and antibiofilm actions of UL-ZnSe NPs and PVP-ZnSe NPs demonstrated moderate inhibition against S. aureus and P. aeruginosa and potent inhibition against C. albicans. Furthermore, the DPPH radical scavenging assays and in vitro anti-inflammatory assessments indicated that UL-ZnSe NPs exhibited high potency (78.4%). Cytotoxicity assays demonstrated high compatibility of UL-ZnSe NPs with normal human fibroblasts (HF) and less compatibility with epidermal carcinoma of the mouth (KB) cell lines. Although metal nanostructures may have promising therapeutic potential, several factors, such as coating agents, can impart unique physicochemical properties, leading to enhanced performance. Here, the functionalization of NPs with ulvan yielded the best output, which could serve as an alternative for synthesizing metal NPs with high potency and minimal side effects.