Scholarlink

<p>Iron oxide nanoparticles (IONPs), particularly magnetite (Fe<sub>3</sub>O<sub>4</sub>), are promising agents for magnetic fluid hyperthermia. This study reports a comprehensive optimization of the chemical co-precipitation method focusing on pH, aging time, and washing solvents to synthesize phase-pure, well-dispersed magnetite nanoparticles exhibiting superparamagnetic behaviour. Synchrotron X-ray diffraction along with Rietveld refinement confirmed the formation of a single-phase inverse cubic spinel structure. Field emission scanning electron microscopy revealed the synthesis of spherical nanoparticles with a size range of 15–25&#xa0;nm. X-ray photoelectron spectroscopy validated the characteristic Fe<sup>2+</sup>/Fe<sup>3+</sup> mixed valance state of magnetite. Magnetic measurements demonstrated saturation magnetization (57.26&#xa0;emu/g at 298&#xa0;K and 64.8&#xa0;emu/g at 5&#xa0;K) and magnetization-temperature analysis indicated a blocking temperature of 115&#xa0;K, confirming superparamagnetism. Hyperthermia studies on the optimized sample exhibited a significant temperature increase (up to 13&#xa0;°C under an 80 Oe AC field at 490&#xa0;kHz) at a low concentration of 2&#xa0;mg/ml, demonstrating strong magneto-thermal efficiency. These results highlight the successful synthesis of high-purity magnetite SPIONs with superior heating performance, underscoring their potential for effective magnetic hyperthermia in cancer therapy.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Optimizing Synthesis Parameters to Achieve Phase-pure Superparamagnetic Fe3O4 Nanoparticles for Magnetic Hyperthermia

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月29日

查看全文
  • Sawan Kumar Bhakar,
  • Bhumika Sharma,
  • Srinibas Satapathy,
  • Pratik Deshmukh,
  • Velaga Srihari,
  • Rashmi Singh,
  • S. K. Majumder

摘要

Iron oxide nanoparticles (IONPs), particularly magnetite (Fe3O4), are promising agents for magnetic fluid hyperthermia. This study reports a comprehensive optimization of the chemical co-precipitation method focusing on pH, aging time, and washing solvents to synthesize phase-pure, well-dispersed magnetite nanoparticles exhibiting superparamagnetic behaviour. Synchrotron X-ray diffraction along with Rietveld refinement confirmed the formation of a single-phase inverse cubic spinel structure. Field emission scanning electron microscopy revealed the synthesis of spherical nanoparticles with a size range of 15–25 nm. X-ray photoelectron spectroscopy validated the characteristic Fe2+/Fe3+ mixed valance state of magnetite. Magnetic measurements demonstrated saturation magnetization (57.26 emu/g at 298 K and 64.8 emu/g at 5 K) and magnetization-temperature analysis indicated a blocking temperature of 115 K, confirming superparamagnetism. Hyperthermia studies on the optimized sample exhibited a significant temperature increase (up to 13 °C under an 80 Oe AC field at 490 kHz) at a low concentration of 2 mg/ml, demonstrating strong magneto-thermal efficiency. These results highlight the successful synthesis of high-purity magnetite SPIONs with superior heating performance, underscoring their potential for effective magnetic hyperthermia in cancer therapy.