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<p>Conventional wound dressings are limited by their inability to provide controlled drug release. This study addresses this issue by developing hydrogel beads composed of alginate and chitosan in different weight ratios, designed for the sustained release of the antibiotic tetracycline. The optimal hydrogel beads were further enhanced by incorporating biocompatible iron oxide–zeolite nanoparticles, which improved drug encapsulation efficiency and system performance. The swelling and drug release behaviors of the hydrogel beads were evaluated under pH conditions simulating the wound microenvironment. Results indicated that the amount of chitosan coating significantly affected both swelling (up to 860% in 2&#xa0;h) and drug release profiles. The formulation of alginate hydrogel beads containing 50% chitosan coating was found to be optimal, achieving 80% tetracycline release over 48&#xa0;h. Further modification with magnetic zeolite nanoparticles led to increased bead stability (45% reduction in weight loss) and swelling capacity (up to 2400%), while also enabling a more controlled drug release with a reduced initial burst. Among various formulations, alginate–chitosan hydrogel beads incorporating 5% magnetic zeolite emerged as the most effective carrier system. Drug release kinetics analysis revealed that tetracycline release from all formulations follows Fickian diffusion, indicating diffusion-controlled mechanisms. Antibacterial testing showed that the optimized hydrogel beads produced inhibition zones of 13&#xa0;mm against <i>Escherichia coli</i> and 30&#xa0;mm against <i>Staphylococcus aureus</i>, demonstrating stronger activity against <i>S. aureus</i>. Overall, these results suggest that the developed bionanocomposite hydrogel beads are promising candidates for use as advanced wound dressings, offering improved drug delivery and antibacterial performance.</p>

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Chitosan-Coated Alginate Hydrogel Beads Incorporating Iron Oxide-Zeolite Nanoparticles for Wound Healing

  • 期刊论文

  • 发表日期：

    2025年8月16日

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  • Mehdi Barzegarzadeh,
  • Hanieh Mohammadian,
  • Mohammad Sadegh Amini-Fazl,
  • Negin Sohrabi

摘要

Conventional wound dressings are limited by their inability to provide controlled drug release. This study addresses this issue by developing hydrogel beads composed of alginate and chitosan in different weight ratios, designed for the sustained release of the antibiotic tetracycline. The optimal hydrogel beads were further enhanced by incorporating biocompatible iron oxide–zeolite nanoparticles, which improved drug encapsulation efficiency and system performance. The swelling and drug release behaviors of the hydrogel beads were evaluated under pH conditions simulating the wound microenvironment. Results indicated that the amount of chitosan coating significantly affected both swelling (up to 860% in 2 h) and drug release profiles. The formulation of alginate hydrogel beads containing 50% chitosan coating was found to be optimal, achieving 80% tetracycline release over 48 h. Further modification with magnetic zeolite nanoparticles led to increased bead stability (45% reduction in weight loss) and swelling capacity (up to 2400%), while also enabling a more controlled drug release with a reduced initial burst. Among various formulations, alginate–chitosan hydrogel beads incorporating 5% magnetic zeolite emerged as the most effective carrier system. Drug release kinetics analysis revealed that tetracycline release from all formulations follows Fickian diffusion, indicating diffusion-controlled mechanisms. Antibacterial testing showed that the optimized hydrogel beads produced inhibition zones of 13 mm against Escherichia coli and 30 mm against Staphylococcus aureus, demonstrating stronger activity against S. aureus. Overall, these results suggest that the developed bionanocomposite hydrogel beads are promising candidates for use as advanced wound dressings, offering improved drug delivery and antibacterial performance.