<p>This study was designed to assess the impact of biological and physical dosimetry on radiography staff exposed to low doses of ionizing radiation. Our unique study involved 40 volunteers, 10 as control group A, and 30 radiology department staff, who were divided into three groups (10 cases for each group): Group B: staff working in X-ray imaging, who are occupationally exposed to diagnostic X-rays. Group C: staff involved in computed tomography (CT) procedures and thus exposed to ionizing radiation from CT imaging. Group D: staff operating C-arm fluoroscopy systems, who are subjected to repeated or prolonged exposure to fluoroscopic X-ray radiation during interventional procedures. Blood samples were collected from all participants for hematological analysis and evaluation of blood indices. Peripheral blood smears were manually prepared and examined microscopically. Serum samples were used to assess liver function enzymes, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total protein, as well as kidney function markers such as urea and creatinine. All participants were fully informed about the study procedures and provided written informed consent prior to blood collection. The study revealed changes in erythrocyte shape and volume, platelet and white blood cell counts, and hemoglobin levels but no significant variations in red blood cell counts. The values for hemoglobin, WBCs, RBCs, and platelets all fall within normal ranges. Semimanual cumulative radiation doses significantly differed among the three groups, with group D having the highest mean dose (0.18&#xa0;mSv) and group C having the lowest (0.13&#xa0;mSv). The study concluded that even low levels of ionizing radiation could have a significant impact on CBC, hepatic, and renal parameters within the normal physiological range. These findings underscore the gravity of the potential health risks associated with radiation exposure.</p>