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<p>Drug administration through the mouth has unique difficulties, especially for poorly absorbed and easily degraded APIs. The medicine’s breakdown, absorption, and release profile may be improved by adding physiologically active molecules to a naturally occurring polymer matrix, which can increase the therapeutic effect and perhaps even decrease the frequency of administration. Hyaluronic acid (HA) is a polymer with remarkable biocompatibility, biodegradability, and unique physicochemical properties. The use of HANPs has great potential as a method of rapid and effective medication delivery throughout the digestive system. When it comes to systemic, cellular biological barriers and microenvironmental, which vary widely between clinical groups, NPs have been designed to overcome the limitations of free therapies. Precision therapies, in which individualized treatments improve on their already high therapeutic success, have also helped to overcome this diversity across patients. Meanwhile, HANPs, as a biocompatible polymer, exhibit intestinal mucosal adherence, which may increase the number of times medications remain at sites of inflammation. There has been an increase in the investigation and creation of HANPs as a colon-targeted oral medication delivery method for treating gastrointestinal disorders and insulin delivery for diabetes. This review intends to deliver a concise summary of the use and therapy of HANPs for GI disorders and insulin administration. Additionally, it will give a glimpse into the future of HANPs as colon-targeted ODDSs, including their potential and development trajectory.</p>

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Advances in Hyaluronic Acid Nanoparticles for Targeted Oral Drug Delivery: Applications in GI Disorders and Insulin Therapy

  • 期刊论文

  • 发表日期：

    2025年7月26日

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  • Richa Rani,
  • Navdeep Singh,
  • Pusuluri Madhubabu,
  • Rekha M M,
  • Mandeep Kaur,
  • Pradeep Soothwal,
  • Isha Arora,
  • M. Ravi Kumar,
  • Ashish Singh Chauhan,
  • Ashish Gaur,
  • Vetriselvan Subramaniyan

摘要

Drug administration through the mouth has unique difficulties, especially for poorly absorbed and easily degraded APIs. The medicine’s breakdown, absorption, and release profile may be improved by adding physiologically active molecules to a naturally occurring polymer matrix, which can increase the therapeutic effect and perhaps even decrease the frequency of administration. Hyaluronic acid (HA) is a polymer with remarkable biocompatibility, biodegradability, and unique physicochemical properties. The use of HANPs has great potential as a method of rapid and effective medication delivery throughout the digestive system. When it comes to systemic, cellular biological barriers and microenvironmental, which vary widely between clinical groups, NPs have been designed to overcome the limitations of free therapies. Precision therapies, in which individualized treatments improve on their already high therapeutic success, have also helped to overcome this diversity across patients. Meanwhile, HANPs, as a biocompatible polymer, exhibit intestinal mucosal adherence, which may increase the number of times medications remain at sites of inflammation. There has been an increase in the investigation and creation of HANPs as a colon-targeted oral medication delivery method for treating gastrointestinal disorders and insulin delivery for diabetes. This review intends to deliver a concise summary of the use and therapy of HANPs for GI disorders and insulin administration. Additionally, it will give a glimpse into the future of HANPs as colon-targeted ODDSs, including their potential and development trajectory.