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<p>This research presents the development and characterization of polyvinylidene fluoride (PVDF) meshes functionalized with a series of bentonite-based nanocomposites, designed for use in abdominal surgical applications. The nanocomposites, composed of bentonite nanoparticles (NB), silver nanoparticles (Ag), levofloxacin (LVF), and propolis (P), were synthesized through a combination of calcination, sonication, and green synthesis techniques. These surface modifications aim to enhance the antimicrobial properties and drug delivery potential of the PVDF meshes. The structural and morphological characteristics of the resulting nanocomposites were analyzed using scanning electron microscopy (SEM). The antimicrobial efficacy of the modified PVDF meshes was assessed against a range of bacterial strains (<i>Staphylococcus aureus</i> 1199, <i>Staphylococcus aureus</i> 1199B, <i>Staphylococcus epidermidis</i> ATCC 14990, <i>Pseudomonas aeruginosa</i>), with the results demonstrating a significant increase in bacterial inhibition in the case of NB@LVF@AgNP@P compared to unmodified meshes. Additionally, the study investigated the diffusion kinetics of levofloxacin through bacterial membranes, highlighting the effectiveness of the nanocomposites in facilitating controlled drug release. These findings suggest that the incorporation of bentonite-based nanocomposites offers a promising approach to enhancing the functionality of PVDF meshes by providing synergistic antimicrobial and drug delivery properties. Such advancements hold considerable potential for improving the performance and therapeutic outcomes of biomedical materials in surgical applications.</p>

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Nanostructured Bentonite-Based Coatings for PVDF Meshes: Antimicrobial Properties and Controlled Drug Release

  • 期刊论文

  • 发表日期：

    2025年6月25日

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  • A. R. Aliyev,
  • U. A. Hasanova,
  • A. A. Israyilova,
  • Z. O. Gakhramanova,
  • A. B. Ahmadova

摘要

This research presents the development and characterization of polyvinylidene fluoride (PVDF) meshes functionalized with a series of bentonite-based nanocomposites, designed for use in abdominal surgical applications. The nanocomposites, composed of bentonite nanoparticles (NB), silver nanoparticles (Ag), levofloxacin (LVF), and propolis (P), were synthesized through a combination of calcination, sonication, and green synthesis techniques. These surface modifications aim to enhance the antimicrobial properties and drug delivery potential of the PVDF meshes. The structural and morphological characteristics of the resulting nanocomposites were analyzed using scanning electron microscopy (SEM). The antimicrobial efficacy of the modified PVDF meshes was assessed against a range of bacterial strains (Staphylococcus aureus 1199, Staphylococcus aureus 1199B, Staphylococcus epidermidis ATCC 14990, Pseudomonas aeruginosa), with the results demonstrating a significant increase in bacterial inhibition in the case of NB@LVF@AgNP@P compared to unmodified meshes. Additionally, the study investigated the diffusion kinetics of levofloxacin through bacterial membranes, highlighting the effectiveness of the nanocomposites in facilitating controlled drug release. These findings suggest that the incorporation of bentonite-based nanocomposites offers a promising approach to enhancing the functionality of PVDF meshes by providing synergistic antimicrobial and drug delivery properties. Such advancements hold considerable potential for improving the performance and therapeutic outcomes of biomedical materials in surgical applications.