<p>E-waste printed circuit boards from outdated electronic devices, including old model computers and FM radios, were processed to extract valuable materials. A 1&#xa0;kg sample of electronic waste printed circuit board was subjected to a leaching process, and the extracted materials were characterized using powder X-ray diffraction, UV–visible spectroscopy, and scanning electron microscopy (SEM). Powder X-ray analysis revealed a cubic crystal structure with space group Fm-3&#xa0;m (CCDC 9012961). UV–visible spectroscopy indicated energy absorption in the visible range (400–410&#xa0;nm), and SEM identified a rod-like surface morphology. Molecular docking studies demonstrated interactions between silver nanoparticles and anticancer/antibiotic molecules via cytochrome P450 (CYP P450) enzymes, revealing their potential for drug interactions. Antioxidant activities, including 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power, and anti-lipid peroxidation assays, were performed, indicating strong antioxidant potential. This study introduces a novel, high-temperature route to obtain phase-pure AgNPs from EWPCBs, with promising applications in drug interaction, oxidative stress reduction, and therapeutic development.</p>

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Electronic Waste-Derived Silver Nanoparticles for Drug Interactions and Antioxidant Applications

  • S. Thiyagaraj,
  • Karthik Kumara,
  • A. S. Giresha,
  • V. Aranganathan

摘要

E-waste printed circuit boards from outdated electronic devices, including old model computers and FM radios, were processed to extract valuable materials. A 1 kg sample of electronic waste printed circuit board was subjected to a leaching process, and the extracted materials were characterized using powder X-ray diffraction, UV–visible spectroscopy, and scanning electron microscopy (SEM). Powder X-ray analysis revealed a cubic crystal structure with space group Fm-3 m (CCDC 9012961). UV–visible spectroscopy indicated energy absorption in the visible range (400–410 nm), and SEM identified a rod-like surface morphology. Molecular docking studies demonstrated interactions between silver nanoparticles and anticancer/antibiotic molecules via cytochrome P450 (CYP P450) enzymes, revealing their potential for drug interactions. Antioxidant activities, including 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power, and anti-lipid peroxidation assays, were performed, indicating strong antioxidant potential. This study introduces a novel, high-temperature route to obtain phase-pure AgNPs from EWPCBs, with promising applications in drug interaction, oxidative stress reduction, and therapeutic development.