Scholarlink

<p>Nanoporous polymeric membranes serve many important functions in industry and medicine. However, in the case of direct contact of the membrane with the internal space of living organisms, the membrane itself needs to be modified to achieve the intended effect related to biocompatibility improvement and increase or reduction of cell adhesion. In the present paper, we have conducted an experimental review of ten different chemical modifications of polycarbonate nanoporous membranes, namely coating with polydopamine, dextran, graphene oxide, poly(acrylic acid), polyvinylpyrrolidone, methylated poly(ethylene glycol), or trichloro (3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane. The modified membranes were subsequently subjected to various analyses, such as scanning electron microscopy, water contact angle measurement, diffusion study with toluidine blue O dye, and finally, cellular adhesion to the membrane’s surface. The results showed that introduced modifications affected the nature of the membranes (hydrophobicity/hydrophilicity) and cell adhesivity, while preserving its separation and diffusion properties in most cases. The presented modification methods can be selected for use depending on the desired properties of the final product and its application.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Different Strategies for Modifying Polycarbonate Membranes to Control Cell Adhesion

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月2日

查看全文
  • Rafał Podgórski,
  • Piotr Kowalczyk,
  • Krystyna Leśnowolska-Wnuczek,
  • Maria Dekarz,
  • Kamil Kopeć,
  • Mateusz Młynek,
  • Jakub Trzciński,
  • Ewa Rybak,
  • Michał Szkop,
  • Tomasz Ciach

摘要

Nanoporous polymeric membranes serve many important functions in industry and medicine. However, in the case of direct contact of the membrane with the internal space of living organisms, the membrane itself needs to be modified to achieve the intended effect related to biocompatibility improvement and increase or reduction of cell adhesion. In the present paper, we have conducted an experimental review of ten different chemical modifications of polycarbonate nanoporous membranes, namely coating with polydopamine, dextran, graphene oxide, poly(acrylic acid), polyvinylpyrrolidone, methylated poly(ethylene glycol), or trichloro (3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane. The modified membranes were subsequently subjected to various analyses, such as scanning electron microscopy, water contact angle measurement, diffusion study with toluidine blue O dye, and finally, cellular adhesion to the membrane’s surface. The results showed that introduced modifications affected the nature of the membranes (hydrophobicity/hydrophilicity) and cell adhesivity, while preserving its separation and diffusion properties in most cases. The presented modification methods can be selected for use depending on the desired properties of the final product and its application.

Graphical Abstract