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<p>This study focuses on synthesizing a novel combination of Resveratrol (Res) and poly-vinylpyrrolidone (PVP) loaded into magnesium oxide nanoparticles (MgO NPs) to enhance the bioactivity of Res. Various techniques were employed to characterize the synthesized NPs in terms of their size, morphology, and structural properties. UV–visible (UV–vis) spectroscopy shows λ<sub>max</sub> at 322&#xa0;nm for free MgO NPs while conjugated (Res-PVP-MgO) NPs λ<sub>max</sub> at 302&#xa0;nm. The mean size of the free MgO and conjugated (Res-PVP-MgO) NPs was found to be 62&#xa0;nm and 84&#xa0;nm respectively. The zeta potential was found to be − 36.4&#xa0;mV and − 64.8&#xa0;mV of MgO and conjugated (Res-PVP-MgO) NPs respectively. The antibacterial activity of the free Res, MgO NPs and conjugated (Res-PVP-MgO) NPs was analyzed against bacterial (<i>B. cereus</i>, <i>B. subtilis</i>, <i>E. coli</i> and <i>P. aeruginosa</i>) considerable cell damage at the target site compared to free Res and MgO NPs at a specific concentration (10&#xa0;μg). Antifungal efficacy of conjugated (Res-PVP-MgO) NPs against fungal strain (<i>Fusarium oxysporum</i>) is showing &gt; 68% significant inhibitory effects compared to free Res and MgO NPs. Additionally, conjugated Res-PVP-MgO NPs exhibited a significant increase in free radical scavenging activity compared to free Res (&gt; 88%). Furthermore, an antiangiogenic assay indicated that conjugated (Res-PVP-MgO) NPs displayed anti-angiogenic properties at 40&#xa0;μg/mL. The conjugated (Res-PVP-MgO) NPs also demonstrated sustained release of Res over a period of 24&#xa0;h at colonic pH (98%), compared to free Res. Comprehensively, Res-PVP-loaded MgO NPs are showing their potential as a multifunctional therapeutic agent for treating various diseases.</p>

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Characterization and Bioactivity Enhancement of Resveratrol with PVP-Loaded MgO Nanoparticles

  • 期刊论文

  • 发表日期：

    2025年6月6日

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  • Parashuram Shivappa,
  • Anjana Thatesh Gaddigal,
  • Manisha Rajendra Mirjankar,
  • Madhu Prakash Ganeshkar,
  • Premakshi Hucharayappa Goder,
  • Vijaykumar Ramesh Karoshi,
  • Chandrappa Mukappa Kamanavalli

摘要

This study focuses on synthesizing a novel combination of Resveratrol (Res) and poly-vinylpyrrolidone (PVP) loaded into magnesium oxide nanoparticles (MgO NPs) to enhance the bioactivity of Res. Various techniques were employed to characterize the synthesized NPs in terms of their size, morphology, and structural properties. UV–visible (UV–vis) spectroscopy shows λmax at 322 nm for free MgO NPs while conjugated (Res-PVP-MgO) NPs λmax at 302 nm. The mean size of the free MgO and conjugated (Res-PVP-MgO) NPs was found to be 62 nm and 84 nm respectively. The zeta potential was found to be − 36.4 mV and − 64.8 mV of MgO and conjugated (Res-PVP-MgO) NPs respectively. The antibacterial activity of the free Res, MgO NPs and conjugated (Res-PVP-MgO) NPs was analyzed against bacterial (B. cereus, B. subtilis, E. coli and P. aeruginosa) considerable cell damage at the target site compared to free Res and MgO NPs at a specific concentration (10 μg). Antifungal efficacy of conjugated (Res-PVP-MgO) NPs against fungal strain (Fusarium oxysporum) is showing > 68% significant inhibitory effects compared to free Res and MgO NPs. Additionally, conjugated Res-PVP-MgO NPs exhibited a significant increase in free radical scavenging activity compared to free Res (> 88%). Furthermore, an antiangiogenic assay indicated that conjugated (Res-PVP-MgO) NPs displayed anti-angiogenic properties at 40 μg/mL. The conjugated (Res-PVP-MgO) NPs also demonstrated sustained release of Res over a period of 24 h at colonic pH (98%), compared to free Res. Comprehensively, Res-PVP-loaded MgO NPs are showing their potential as a multifunctional therapeutic agent for treating various diseases.