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<p>Iron oxide nanoparticles were mycosynthesized (M.FeONPs) using an aqueous extract of <i>Arthrinium aureum</i>, an endophytic fungus from <i>Aegiceras corniculatum</i>, and compared with chemically synthesized iron oxide nanoparticles (FeONPs) for their angiogenic and wound healing properties. The findings suggest that M.FeONPs enhanced cell proliferation, viability, migration, and capillary-like tube formation in endothelial cells [EA.hy926 cells and human umbilical vein endothelial cells (HUVECs)]. Furthermore, it upregulates the gene expression of eNOS and VEGF. In contrast, FeONPs did not show these effects during the study of angiogenesis. Similarly, the M.FeONPs improved the blood micro-vasculature formation in chick embryos assay and also observed the accelerated wound healing through increased blood flow around the wound area in an animal model. This pro-angiogenic activity of M.FeONPs is linked to the upregulation of NOX (NADPH oxidase 2) and activation of the PI3K/Akt/MAPK pathway. Based on the safety assessment results and non-immunogenicity studies, M.FeONPs could be a promising bio-compatible&#xa0;and pro-angiogenic agent for treating various vascular-related&#xa0;diseases (wound healing, ischemic).</p> Graphical Abstract <p></p>

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Investigation of Pro-angiogenic and Wound Healing Activity of Mycosynthesized Iron-Oxide Nanoparticles

  • 期刊论文

  • 发表日期：

    2025年5月30日

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  • Asha Priya Mandarada,
  • Arpita Roy,
  • Sunil Misra,
  • Chitta Ranjan Patra,
  • Srinivasa Rao Mutheneni

摘要

Iron oxide nanoparticles were mycosynthesized (M.FeONPs) using an aqueous extract of Arthrinium aureum, an endophytic fungus from Aegiceras corniculatum, and compared with chemically synthesized iron oxide nanoparticles (FeONPs) for their angiogenic and wound healing properties. The findings suggest that M.FeONPs enhanced cell proliferation, viability, migration, and capillary-like tube formation in endothelial cells [EA.hy926 cells and human umbilical vein endothelial cells (HUVECs)]. Furthermore, it upregulates the gene expression of eNOS and VEGF. In contrast, FeONPs did not show these effects during the study of angiogenesis. Similarly, the M.FeONPs improved the blood micro-vasculature formation in chick embryos assay and also observed the accelerated wound healing through increased blood flow around the wound area in an animal model. This pro-angiogenic activity of M.FeONPs is linked to the upregulation of NOX (NADPH oxidase 2) and activation of the PI3K/Akt/MAPK pathway. Based on the safety assessment results and non-immunogenicity studies, M.FeONPs could be a promising bio-compatible and pro-angiogenic agent for treating various vascular-related diseases (wound healing, ischemic).

Graphical Abstract