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<p>Silver ferrite nanoparticles (AgFeO<sub>2</sub> NPs) were successfully synthesized using a co-precipitation method and characterized through a comprehensive array of analytical techniques. Structural confirmation of AgFeO<sub>2</sub> was achieved through FTIR and XRD, while TEM analysis revealed uniformly spherical nanoparticles with an average diameter of 28 ± 3&#xa0;nm. Surface morphology and elemental composition were investigated using SEM and EDX, while DLS measurements indicated a slightly larger average size of 71.02&#xa0;nm, attributed to minor aggregation in solution. Magnetic analysis via vibrating sample magnetometry (VSM) demonstrated the soft magnetic nature of AgFeO<sub>2</sub> nanoparticles, with a saturation magnetization (3.5760&#xa0;emu/g). The in vitro heating efficiency of AgFeO<sub>2</sub> NPs was assessed through specific absorption rate (SAR) measurements in water and sodium citrate media, yielding values of 800 W/g and 1420 W/g, respectively, underscoring their potential in hyperthermia applications. Cytotoxicity studies using the MTT assay revealed dose-dependent effects across a range of cancer cell lines, including HepG-2, HCT-116, MCF-7, and A-549, with IC<sub>50</sub> values of 19.70&#xa0;μg/mL, 45.48&#xa0;μg/mL, 52.78&#xa0;μg/mL, and 28.79&#xa0;μg/mL, respectively. Remarkably, AgFeO<sub>2</sub> NPs exhibited selective cytotoxicity, as indicated by their higher CC<sub>50</sub> value of 73.01&#xa0;μg/mL in normal WI-38 cells, demonstrating preferential toxicity toward cancer cells while sparing normal cells. These results highlight the promise of AgFeO<sub>2</sub> nanoparticles as a versatile material for cancer therapy, combining their capability for hyperthermia treatment with selective anti-cancer activity.</p>

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Preparation and Characterization of Silver Ferrite Nanoparticles (AgFeO2) and Investigation of Their Cytotoxicity Properties

  • 期刊论文

  • 发表日期：

    2025年5月20日

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  • Asmaa Sayed,
  • Ahmed S. Hiekal,
  • Saber I. Moussa,
  • Mohamed I. Aydia,
  • Hanan A. El-Sabagh,
  • Ghada A. Mahmoud,
  • Abeer M. Amin,
  • Khaled M. El-Azony

摘要

Silver ferrite nanoparticles (AgFeO2 NPs) were successfully synthesized using a co-precipitation method and characterized through a comprehensive array of analytical techniques. Structural confirmation of AgFeO2 was achieved through FTIR and XRD, while TEM analysis revealed uniformly spherical nanoparticles with an average diameter of 28 ± 3 nm. Surface morphology and elemental composition were investigated using SEM and EDX, while DLS measurements indicated a slightly larger average size of 71.02 nm, attributed to minor aggregation in solution. Magnetic analysis via vibrating sample magnetometry (VSM) demonstrated the soft magnetic nature of AgFeO2 nanoparticles, with a saturation magnetization (3.5760 emu/g). The in vitro heating efficiency of AgFeO2 NPs was assessed through specific absorption rate (SAR) measurements in water and sodium citrate media, yielding values of 800 W/g and 1420 W/g, respectively, underscoring their potential in hyperthermia applications. Cytotoxicity studies using the MTT assay revealed dose-dependent effects across a range of cancer cell lines, including HepG-2, HCT-116, MCF-7, and A-549, with IC50 values of 19.70 μg/mL, 45.48 μg/mL, 52.78 μg/mL, and 28.79 μg/mL, respectively. Remarkably, AgFeO2 NPs exhibited selective cytotoxicity, as indicated by their higher CC50 value of 73.01 μg/mL in normal WI-38 cells, demonstrating preferential toxicity toward cancer cells while sparing normal cells. These results highlight the promise of AgFeO2 nanoparticles as a versatile material for cancer therapy, combining their capability for hyperthermia treatment with selective anti-cancer activity.