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<p>Nanotechnology has revolutionized drug delivery systems by enhancing efficacy and minimizing side effects compared to traditional treatments like chemotherapy. This study introduces a novel approach using a double-emulsion technique to fabricate a gelatin (G)/carboxymethylcellulose (CMC)/carbon nanotubes (CNTs)-based nanocomposite hydrogel loaded with curcumin (Cur) to target MCF-7 cell lines. Curcumin, known for its anti-inflammatory and anticancer properties, faces challenges in stability and bioavailability, which this method aims to overcome. Various analyses (XRD, FTIR, FESEM, DLS) confirmed successful synthesis and Cur loading within the. nanocarrier. Results indicated efficient drug placement and preservation of the crystalline properties of the nanomaterials. Distribution of CNTs was uniform and stable, which is crucial for drug delivery systems. The pH-sensitive nanocomposite hydrogel exhibited controlled drug release within cancerous acidic environments, minimizing damage to healthy cells. The nanocarrier achieved a high loading capacity (46 ± 0.25%) and entrapment efficiency (87 ± 0.3%). Assessment using the MTT assay on MCF-7 and L929 cell lines demonstrated significant cytotoxicity. Flow cytometry evaluated apoptosis and necrosis induced by the drug-loaded nanocomposite. Overall, the developed nanocomposite is a biocompatible carrier improving Cur delivery efficacy for breast cancer treatment by enhancing drug loading, stable release, and cytotoxicity against MCF-7 cells, thus potentially improving cancer treatment outcomes.&#xa0;</p> Graphical Abstract <p></p>

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Gelatin/Carboxymethylcellulose Incorporated CNTs Nanocarrier Synthesis Targeted Delivery of Curcumin

  • 期刊论文

  • 发表日期：

    2025年5月27日

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  • Mahdieh Sadat Mousavi,
  • Mehrab Pourmadadi,
  • Majid Abdouss,
  • Saeedeh Mazinani,
  • Abbas Rahdar,
  • Sonia Fathi-Karkan,
  • Luiz Fernando Romanholo Ferreira

摘要

Nanotechnology has revolutionized drug delivery systems by enhancing efficacy and minimizing side effects compared to traditional treatments like chemotherapy. This study introduces a novel approach using a double-emulsion technique to fabricate a gelatin (G)/carboxymethylcellulose (CMC)/carbon nanotubes (CNTs)-based nanocomposite hydrogel loaded with curcumin (Cur) to target MCF-7 cell lines. Curcumin, known for its anti-inflammatory and anticancer properties, faces challenges in stability and bioavailability, which this method aims to overcome. Various analyses (XRD, FTIR, FESEM, DLS) confirmed successful synthesis and Cur loading within the. nanocarrier. Results indicated efficient drug placement and preservation of the crystalline properties of the nanomaterials. Distribution of CNTs was uniform and stable, which is crucial for drug delivery systems. The pH-sensitive nanocomposite hydrogel exhibited controlled drug release within cancerous acidic environments, minimizing damage to healthy cells. The nanocarrier achieved a high loading capacity (46 ± 0.25%) and entrapment efficiency (87 ± 0.3%). Assessment using the MTT assay on MCF-7 and L929 cell lines demonstrated significant cytotoxicity. Flow cytometry evaluated apoptosis and necrosis induced by the drug-loaded nanocomposite. Overall, the developed nanocomposite is a biocompatible carrier improving Cur delivery efficacy for breast cancer treatment by enhancing drug loading, stable release, and cytotoxicity against MCF-7 cells, thus potentially improving cancer treatment outcomes. 

Graphical Abstract