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<p>Wound dressings are crucial for promoting healing and preventing infections, with nanomaterials offering innovative solutions. This study develops multifunctional dodecylamine-grafted oxidized pectin-based electrospun nanofibers incorporating grape seed extract (GSE), addressing key wound healing challenges. Polyvinyl alcohol (PVA) serves as the primary nanofiber backbone, providing structural integrity. The nanofiber preparation involved oxidizing pectin to introduce aldehyde groups, aminating with dodecylamine, and blending with PVA for electrospinning. FTIR analysis confirmed successful oxidation, amination, and grape seed extract incorporation. Scanning electron microscopy revealed uniform nanofibers with diameters ranging from 57 to 148 nm, while X-ray diffraction showed a consistent semi-crystalline structure across different pectin concentrations. Mechanical characterization demonstrated significant improvements in material properties. Tensile strength increased from 6.92 to 14.61 MPa, and Young's modulus rose from 9.23 to 32.62 MPa as pectin content increased from 10 to 20%. Antimicrobial testing highlighted the nanofibers' effectiveness against <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, and <i>Candida albicans</i>, with enhanced activity in grape seed extract-incorporated samples. The synergistic combination of pectin's biocompatibility, PVA's structural support, dodecylamine's antimicrobial properties, and grape seed extract's natural healing capabilities creates a comprehensive wound dressing solution. This innovative approach demonstrates the potential for sustainable medical product development using plant-based materials.</p>

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PVA/Dodecylamine-Linked Pectin Electrospun Pads Enriched With Grape Seed Extract for Wound Dressing

  • 期刊论文

  • 发表日期：

    2025年5月19日

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  • Sana Babazadeh,
  • Samin Hamidi,
  • Nastaran Alipour,
  • Hadi Sadeghzadeh,
  • Parina Asgharian

摘要

Wound dressings are crucial for promoting healing and preventing infections, with nanomaterials offering innovative solutions. This study develops multifunctional dodecylamine-grafted oxidized pectin-based electrospun nanofibers incorporating grape seed extract (GSE), addressing key wound healing challenges. Polyvinyl alcohol (PVA) serves as the primary nanofiber backbone, providing structural integrity. The nanofiber preparation involved oxidizing pectin to introduce aldehyde groups, aminating with dodecylamine, and blending with PVA for electrospinning. FTIR analysis confirmed successful oxidation, amination, and grape seed extract incorporation. Scanning electron microscopy revealed uniform nanofibers with diameters ranging from 57 to 148 nm, while X-ray diffraction showed a consistent semi-crystalline structure across different pectin concentrations. Mechanical characterization demonstrated significant improvements in material properties. Tensile strength increased from 6.92 to 14.61 MPa, and Young's modulus rose from 9.23 to 32.62 MPa as pectin content increased from 10 to 20%. Antimicrobial testing highlighted the nanofibers' effectiveness against Staphylococcus aureus, Escherichia coli, and Candida albicans, with enhanced activity in grape seed extract-incorporated samples. The synergistic combination of pectin's biocompatibility, PVA's structural support, dodecylamine's antimicrobial properties, and grape seed extract's natural healing capabilities creates a comprehensive wound dressing solution. This innovative approach demonstrates the potential for sustainable medical product development using plant-based materials.