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<p>Prostate cancer is the second most common cause of death among men. In this study, we have developed a low-cost electrochemical immunosensor with a triangular gold nanocrystal-modified gold electrode (GE), which provided a highly sensitive detection of prostate-specific antigen (PSA), a key prostate cancer biomarker. Field emission scanning electron microscopy (FESEM) measurements confirmed the nanostructured surface in this electrode, which provided enhancements in sensitivity and selectivity for PSA detection. The electrode’s performance was further validated by electrochemical methods such as cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). In contrast, differential pulse voltammetry (DPV) studies showed a wide detectable range from 1&#xa0;pg&#xa0;mL⁻<sup>1</sup> up to 200&#xa0;ng&#xa0;mL⁻<sup>1</sup> with a low limit of detection (LOD) of ~ 0.10&#xa0;pg&#xa0;mL⁻<sup>1</sup>. The immunosensor exhibited excellent selectivity, reproducibility, and regeneration. Its simplicity and possible use at the point-of-care represent a huge advance in the early diagnosis of prostate cancer.</p> Graphical Abstract <p></p>

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A Modified Gold Electrode with Triangular Gold Nanocrystals; Application as an Immunosensor for Early Diagnosis of Prostate Cancer

  • 期刊论文

  • 发表日期：

    2025年5月21日

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  • Masoud Negahdary,
  • Mateus de Almeida Batista,
  • Rafael Martos Buoro,
  • Mauricio S. Baptista,
  • Ivano Gebhardt Rolf Gutz,
  • Lúcio Angnes

摘要

Prostate cancer is the second most common cause of death among men. In this study, we have developed a low-cost electrochemical immunosensor with a triangular gold nanocrystal-modified gold electrode (GE), which provided a highly sensitive detection of prostate-specific antigen (PSA), a key prostate cancer biomarker. Field emission scanning electron microscopy (FESEM) measurements confirmed the nanostructured surface in this electrode, which provided enhancements in sensitivity and selectivity for PSA detection. The electrode’s performance was further validated by electrochemical methods such as cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). In contrast, differential pulse voltammetry (DPV) studies showed a wide detectable range from 1 pg mL⁻1 up to 200 ng mL⁻1 with a low limit of detection (LOD) of ~ 0.10 pg mL⁻1. The immunosensor exhibited excellent selectivity, reproducibility, and regeneration. Its simplicity and possible use at the point-of-care represent a huge advance in the early diagnosis of prostate cancer.

Graphical Abstract