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<p>Biopolymer-based hydrogels are biocompatible and biodegradable, which are potential sources of prolonged and controlled drug release, along with the metal oxide nanoparticles. The synthetic biopolymer polyvinyl alcohol (PVA) was cross-linked by using boric acid which turned into the 3D structure hydrogel. The silver oxide (AgO) nanoparticles were incorporated in the hydrogel by an in situ method by immersion of dried PVA hydrogel in different concentrations (0, 1%, 2%, 3%, and 4%) of silver nitrate solution for 48&#xa0;h, and then it was immersed in NaOH solution for 24&#xa0;h to convert silver ions into silver oxide nanoparticles. The antibacterial drug spectinomycin was loaded by the in situ method on PVA/AgO nanocomposites hydrogel, and its swelling behavior, antibacterial activities, and drug load-release were also evaluated. Swelling behavior was examined in distilled water, buffer solutions, and salts, which showed maximum swelling in water and at pH 7.4. The Raman spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscope, and X-ray diffraction characterization techniques were used for the surface morphology, structural investigation, and identification of nanoparticles in the polymer matrix. Cytotoxicity was performed by using human liver cancer cell line (HepG2). Controlled drug release from hydrogel was analyzed in a 7.4 pH phosphate buffer solution. Drug release concentrations were analyzed by UV–VIS spectrophotometer and Raman spectroscopy coupled with partial least squares regression (PLSR). The results showed that C3 compound was a considerable slow and controlled drug release agent in about 32&#xa0;h and showed more antibacterial activity than C0, C2, and C4.</p>

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Spectinomycin-Loaded Antibacterial Polyvinyl Alcohol/Silver Oxide Nanobiocomposite Hydrogel: Synthesis, Characterization, Swelling, Cytotoxicity, and Controlled Drug Release Carrier

  • 期刊论文

  • 发表日期：

    2025年4月25日

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  • Abdul Naman,
  • Anfal Fatima,
  • Nasir Mehmood,
  • Minseok Kim,
  • Sobia Younas

摘要

Biopolymer-based hydrogels are biocompatible and biodegradable, which are potential sources of prolonged and controlled drug release, along with the metal oxide nanoparticles. The synthetic biopolymer polyvinyl alcohol (PVA) was cross-linked by using boric acid which turned into the 3D structure hydrogel. The silver oxide (AgO) nanoparticles were incorporated in the hydrogel by an in situ method by immersion of dried PVA hydrogel in different concentrations (0, 1%, 2%, 3%, and 4%) of silver nitrate solution for 48 h, and then it was immersed in NaOH solution for 24 h to convert silver ions into silver oxide nanoparticles. The antibacterial drug spectinomycin was loaded by the in situ method on PVA/AgO nanocomposites hydrogel, and its swelling behavior, antibacterial activities, and drug load-release were also evaluated. Swelling behavior was examined in distilled water, buffer solutions, and salts, which showed maximum swelling in water and at pH 7.4. The Raman spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscope, and X-ray diffraction characterization techniques were used for the surface morphology, structural investigation, and identification of nanoparticles in the polymer matrix. Cytotoxicity was performed by using human liver cancer cell line (HepG2). Controlled drug release from hydrogel was analyzed in a 7.4 pH phosphate buffer solution. Drug release concentrations were analyzed by UV–VIS spectrophotometer and Raman spectroscopy coupled with partial least squares regression (PLSR). The results showed that C3 compound was a considerable slow and controlled drug release agent in about 32 h and showed more antibacterial activity than C0, C2, and C4.