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<p>An extracellular matrix-mimicking, biodegradable tissue-engineered electrospun polymeric nanofibers represent a novel class of wound dressing within which pro- and anti-apoptotic functions can be precisely regulated resulting in effective wound management. Increased matrix metalloproteinases (MMPs) level contributes to recalcitrant wound healing, specifically ablating the growth factors and other pro-healing molecules, hindering the healing process. Shikonin, a naphthoquinone pigment, has drawn attention for its ability to reduce inflammation, fight microbes, regulate diabetes, and influence MMP- 9 activity, making it a promising candidate for diabetic wound treatment. The compound’s low aqueous solubility and photosensitivity necessitate innovative delivery methods to achieve its therapeutic efficacy. The study, thus, aims to develop Shikonin microsponges (SHK-MS)-based electrospun scaffolds. The architecture and fiber structure of the scaffolds were examined using scanning electron microscopy, and the chemical composition, changes in the crystalline structure, homogeneity, and thermal stability of the nanofiber scaffolds and SHK-MS were determined using Fourier-transform infrared spectroscopy, X-ray diffraction, and thermogravimetric analysis, respectively. The visual inspection of excision wounds, histopathological results, and MMP- 9 assays clearly indicate accelerated wound closure, improved tissue restoration, and recovering dermal and epidermal structures as well as skin appendages and adipose tissue exhibiting greater healing potential as compared to the negative control.</p>

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Fabrication of Starch Nanofibrous Scaffolds Co-loaded with Shikonin Microsponges for Accelerated Diabetic Wound Healing: Deciphering In Vitro Insights and In Vivo Realities

  • 期刊论文

  • 发表日期：

    2025年5月6日

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  • Aditi Monga,
  • Kirandeep Kaur,
  • Sahil Gasso,
  • Gurdeep Singh,
  • Dilpreet Singh,
  • Sonal Sethi,
  • Sugam Kumar,
  • Vinod K. Aswal,
  • Fernando González Martínez,
  • Aman Mahajan,
  • Neena Bedi

摘要

An extracellular matrix-mimicking, biodegradable tissue-engineered electrospun polymeric nanofibers represent a novel class of wound dressing within which pro- and anti-apoptotic functions can be precisely regulated resulting in effective wound management. Increased matrix metalloproteinases (MMPs) level contributes to recalcitrant wound healing, specifically ablating the growth factors and other pro-healing molecules, hindering the healing process. Shikonin, a naphthoquinone pigment, has drawn attention for its ability to reduce inflammation, fight microbes, regulate diabetes, and influence MMP- 9 activity, making it a promising candidate for diabetic wound treatment. The compound’s low aqueous solubility and photosensitivity necessitate innovative delivery methods to achieve its therapeutic efficacy. The study, thus, aims to develop Shikonin microsponges (SHK-MS)-based electrospun scaffolds. The architecture and fiber structure of the scaffolds were examined using scanning electron microscopy, and the chemical composition, changes in the crystalline structure, homogeneity, and thermal stability of the nanofiber scaffolds and SHK-MS were determined using Fourier-transform infrared spectroscopy, X-ray diffraction, and thermogravimetric analysis, respectively. The visual inspection of excision wounds, histopathological results, and MMP- 9 assays clearly indicate accelerated wound closure, improved tissue restoration, and recovering dermal and epidermal structures as well as skin appendages and adipose tissue exhibiting greater healing potential as compared to the negative control.