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<p>Radiation dosimetry measures the absorbed dose from ionizing radiation, crucial for safe and accurate radiotherapy applications. Gel dosimetry is a great way to measure 3D doses because it can compare doses to different types of human tissue and combine doses. It does this by measuring chemical changes that happen when people are exposed to radiation. Recent advances in nanoparticle-enhanced gel dosimetry have leveraged the unique properties of high-Z metals, such as copper oxide nanoparticles (CuO NPs), to increase dosimetric sensitivity. The main goal of this study is to make stable CuO NPs using laser ablation and figure out the best way to incorporate them into a PMMAG polymer gel dosimeter. Stability and characterization of CuO NPs were assessed through zeta potential, X-ray diffraction (XRD), and Field Emission-Scanning Electron Microscopy (FE-SEM) analysis. Stability enhancement minimized agglomeration, resulting in more uniform dispersion within PMMAG. Adding CuO NPs made the dosimeter’s sound properties, like speed and attenuation, much better, which was related to the radiation dose and nanoparticle concentration. The acoustic properties varied dose-dependently, especially at concentrations between 1 and 3%, offering optimal sensitivity and stability. Findings reveal the potential of CuO NPs in advancing PMMAG dosimetry by improving acoustic sensitivity and facilitating precise and reproducible radiation dose measurements crucial for clinical applications in radiation therapy. This research highlights the value of stable, well-dispersed nanoparticles for enhancing acoustic-based dosimeters, contributing to more reliable and accurate radiation therapy dosimetry. This study establishes that CuO NPs can enhance the acoustic properties of PMMAG dosimeters, advancing the efficacy and reliability of gel dosimetry in radiotherapy applications.</p>

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Enhancing the Acoustic Properties for a Novel Radiation Dosimetry PMMAG by Optimizing the Stability of Copper Oxide Nanoparticles

  • 期刊论文

  • 发表日期：

    2025年3月19日

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  • Mohammed Dawood Salman,
  • Yasmin Md Radzi,
  • Ammar A. Oglat,
  • Rasha W. Kolaib,
  • Ali Saleh Alkadem Idris,
  • Muhammad Alhassan,
  • Wisam Abdullah Alton,
  • Azhar Abdul Rahman

摘要

Radiation dosimetry measures the absorbed dose from ionizing radiation, crucial for safe and accurate radiotherapy applications. Gel dosimetry is a great way to measure 3D doses because it can compare doses to different types of human tissue and combine doses. It does this by measuring chemical changes that happen when people are exposed to radiation. Recent advances in nanoparticle-enhanced gel dosimetry have leveraged the unique properties of high-Z metals, such as copper oxide nanoparticles (CuO NPs), to increase dosimetric sensitivity. The main goal of this study is to make stable CuO NPs using laser ablation and figure out the best way to incorporate them into a PMMAG polymer gel dosimeter. Stability and characterization of CuO NPs were assessed through zeta potential, X-ray diffraction (XRD), and Field Emission-Scanning Electron Microscopy (FE-SEM) analysis. Stability enhancement minimized agglomeration, resulting in more uniform dispersion within PMMAG. Adding CuO NPs made the dosimeter’s sound properties, like speed and attenuation, much better, which was related to the radiation dose and nanoparticle concentration. The acoustic properties varied dose-dependently, especially at concentrations between 1 and 3%, offering optimal sensitivity and stability. Findings reveal the potential of CuO NPs in advancing PMMAG dosimetry by improving acoustic sensitivity and facilitating precise and reproducible radiation dose measurements crucial for clinical applications in radiation therapy. This research highlights the value of stable, well-dispersed nanoparticles for enhancing acoustic-based dosimeters, contributing to more reliable and accurate radiation therapy dosimetry. This study establishes that CuO NPs can enhance the acoustic properties of PMMAG dosimeters, advancing the efficacy and reliability of gel dosimetry in radiotherapy applications.