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<p>Carbon dots (CDs) are promising carbon-based nanomaterials with a wide range of applications. In this study, various synthetic strategies were used to prepare carbon dots from different precursor molecules, including citric acid, urea, and antibiotics. A facile method using the technique of carbonization was used to prepare luminescent carbon dots. In addition to that, a microwave-assisted method was utilized for synthesizing antibiotic-derived carbon dots, as well as for doping these carbon dots to enhance their crystallinity and narrow their emission peaks. The luminescent properties of the synthesized carbon dots differed based on the synthesis methods and precursors used. Comparative analysis of their antibacterial efficacy indicated that carbon dots derived from citric acid and urea were more effective in inhibiting bacterial growth compared to those based on antibiotics. However, the antibiotic-derived carbon dots exhibited a long-lasting antibacterial effect. Additionally, the impact of carbon dots on bacterial morphology and their subsequent size is examined, leading to the suggestion of developing non-antibiotic antibacterial agents to address the challenges posed by multidrug resistance (MDR).</p>

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Facile Synthesis of Carbon Dots and Their Potential Applications Against Multidrug Resistance (MDR)

  • 期刊论文

  • 发表日期：

    2025年3月19日

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  • Syed Ubaid Qurashi,
  • Larub Younis,
  • Sadaf Nazir,
  • Umar Manzoor,
  • Saima Masood,
  • Faheem A. Sheikh,
  • Shafquat Majeed

摘要

Carbon dots (CDs) are promising carbon-based nanomaterials with a wide range of applications. In this study, various synthetic strategies were used to prepare carbon dots from different precursor molecules, including citric acid, urea, and antibiotics. A facile method using the technique of carbonization was used to prepare luminescent carbon dots. In addition to that, a microwave-assisted method was utilized for synthesizing antibiotic-derived carbon dots, as well as for doping these carbon dots to enhance their crystallinity and narrow their emission peaks. The luminescent properties of the synthesized carbon dots differed based on the synthesis methods and precursors used. Comparative analysis of their antibacterial efficacy indicated that carbon dots derived from citric acid and urea were more effective in inhibiting bacterial growth compared to those based on antibiotics. However, the antibiotic-derived carbon dots exhibited a long-lasting antibacterial effect. Additionally, the impact of carbon dots on bacterial morphology and their subsequent size is examined, leading to the suggestion of developing non-antibiotic antibacterial agents to address the challenges posed by multidrug resistance (MDR).