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<p>Androgenic alopecia (AGA) is a prevalent hair-related polygenetic disorder that causes significant hair loss. Minoxidil (MIN), an FDA-approved drug, is frequently utilized for treatment against AGA. The topical formulations of MIN pose several side effects like erythema and dermatitis upon its frequent application. The purpose of this study was to formulate MIN-loaded polymeric nanoparticles (MIN-NPs) using biodegradable polymers like chitosan and hyaluronic acid and load them in a Carbopol-based hydrogel to enhance their topical delivery and safe application. Chitosan and hyaluronic acid were used as vehicles to enhance permeation via nanoparticle formulation and hydration, respectively. The MIN-NPs were developed via ionic gelation technique and optimized through design expert version 13.0. The optimized nanoparticles exhibited a suitable nanometric size for topical delivery. A longer release profile of MIN was observed, lasting up to 24 h, which occurred from the optimized formulation. <i>Ex vivo</i> permeability analysis exhibited twice the permeability of the drug from MIN-NP hydrogel in comparison to the simple MIN hydrogel. ER value suggested that MIN-NP gel had 2.09 times greater permeability in comparison to simple gel. Fluorescent studies further showed boosted permeability of MIN across stratum corneum. In vivo, skin irritation performed on MIN-NP hydrogel showed no local irritation upon application which deemed the formulation safe for topical use to treat androgenic alopecia.</p> Graphical Abstract <p></p>

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Minoxidil Nano-hydrogel Based on Chitosan and Hyaluronic Acid for Potential Treatment of Androgenic Alopecia

  • 期刊论文

  • 发表日期：

    2025年3月6日

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  • Khushbakht Saleem,
  • Bazla Siddiqui,
  • Asim ur.Rehman,
  • Kifayat Ullah Shah,
  • Naveed Ahmed

摘要

Androgenic alopecia (AGA) is a prevalent hair-related polygenetic disorder that causes significant hair loss. Minoxidil (MIN), an FDA-approved drug, is frequently utilized for treatment against AGA. The topical formulations of MIN pose several side effects like erythema and dermatitis upon its frequent application. The purpose of this study was to formulate MIN-loaded polymeric nanoparticles (MIN-NPs) using biodegradable polymers like chitosan and hyaluronic acid and load them in a Carbopol-based hydrogel to enhance their topical delivery and safe application. Chitosan and hyaluronic acid were used as vehicles to enhance permeation via nanoparticle formulation and hydration, respectively. The MIN-NPs were developed via ionic gelation technique and optimized through design expert version 13.0. The optimized nanoparticles exhibited a suitable nanometric size for topical delivery. A longer release profile of MIN was observed, lasting up to 24 h, which occurred from the optimized formulation. Ex vivo permeability analysis exhibited twice the permeability of the drug from MIN-NP hydrogel in comparison to the simple MIN hydrogel. ER value suggested that MIN-NP gel had 2.09 times greater permeability in comparison to simple gel. Fluorescent studies further showed boosted permeability of MIN across stratum corneum. In vivo, skin irritation performed on MIN-NP hydrogel showed no local irritation upon application which deemed the formulation safe for topical use to treat androgenic alopecia.

Graphical Abstract