Scholarlink

<p>Biofilms are the secretions of the selected bacterial species and are rich sources of nutrients, proteins, lipids, and polysaccharides, which form the extracellular polymeric substance matrix. Such gluing structures enable the bacterial assembled colonies to aggregate at one particular place over the available surface. The enclosed biofilms outlining the bacterial colonies shield the bacteria from antibiotics, resulting in novel antimicrobial resistance development against such antibiotics. Designing and proposing novel and tailor-made nano-scaled antibiotics would be a remedial step in the fight against dreaded bacterial pathogens. In this study, such a potential carbon-based biocompatible nano-scaled material named reduced graphene oxide (rGO) nanosheets have been synthesized using modified Hummer’s method and were characterized using Fourier-transform infra-red spectroscopy (FT-IR), UV–Vis spectroscopy, Raman spectroscopy, field-emission scanning electron microscopy (FE-SEM), and transmission electron microscopy (HR-TEM), respectively. The as-observed sheets exhibit a wavy undulated surface topology which, when introduced into the extracted bacterial biofilms obtained from species of <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, exhibited a robust rate of perturbation in the native structure of the synthesized bacterial biofilms. At the end of 72&#xa0;h and 96&#xa0;h, the rGO nanosheets could effectively destroy the biofilm formation up to 98% for <i>E. coli</i> and <i>S. aureus</i>. The damage and leaking-out rate and proportions of the bacterial biofilms upon rGO treatment indicate the lethal and biocidal effect of rGO nanosheets over the as-formed biofilms. Such a study could develop potential nano-scaled novel antibiotics that outcompete conventional antibiotic activities, thereby overcoming the antimicrobial resistance (AMR) properties.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Frustrating the Serenity of Bacterial Biofilms by Bristly Reduced Graphene Oxide Sheets

  • 期刊论文

  • 发表日期：

    2025年2月26日

查看全文
  • Kunal Biswas,
  • Devadass Jessy Mercy,
  • Saranya Udayakumar,
  • Agnishwar Girigoswami,
  • Koyeli Girigoswami

摘要

Biofilms are the secretions of the selected bacterial species and are rich sources of nutrients, proteins, lipids, and polysaccharides, which form the extracellular polymeric substance matrix. Such gluing structures enable the bacterial assembled colonies to aggregate at one particular place over the available surface. The enclosed biofilms outlining the bacterial colonies shield the bacteria from antibiotics, resulting in novel antimicrobial resistance development against such antibiotics. Designing and proposing novel and tailor-made nano-scaled antibiotics would be a remedial step in the fight against dreaded bacterial pathogens. In this study, such a potential carbon-based biocompatible nano-scaled material named reduced graphene oxide (rGO) nanosheets have been synthesized using modified Hummer’s method and were characterized using Fourier-transform infra-red spectroscopy (FT-IR), UV–Vis spectroscopy, Raman spectroscopy, field-emission scanning electron microscopy (FE-SEM), and transmission electron microscopy (HR-TEM), respectively. The as-observed sheets exhibit a wavy undulated surface topology which, when introduced into the extracted bacterial biofilms obtained from species of Escherichia coli and Staphylococcus aureus, exhibited a robust rate of perturbation in the native structure of the synthesized bacterial biofilms. At the end of 72 h and 96 h, the rGO nanosheets could effectively destroy the biofilm formation up to 98% for E. coli and S. aureus. The damage and leaking-out rate and proportions of the bacterial biofilms upon rGO treatment indicate the lethal and biocidal effect of rGO nanosheets over the as-formed biofilms. Such a study could develop potential nano-scaled novel antibiotics that outcompete conventional antibiotic activities, thereby overcoming the antimicrobial resistance (AMR) properties.