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<p>This study explores the physicochemical properties, bioactivity, and catalytic potential of quantum dots capped with ascorbic acid (ASC.QDS), berberine (BER.QDS), and glutathione (GLU.QDS) for biomedical and environmental applications. UV–Vis absorption spectra revealed distinct peaks, with ASC.QDS at ~ 350&#xa0;nm, BER.QDS at lower intensity, and GLU.QDS exhibiting dual peaks at 280&#xa0;nm and 350&#xa0;nm. FTIR and Raman spectroscopy confirmed functional groups such as O–H, C = O, and C–H, indicating surface hydroxylation and functionalization across all samples. Zeta potential analysis suggested moderate stability for ASC.QDS (− 9.64&#xa0;mV) and GLU.QDS (− 9.69&#xa0;mV), whereas BER.QDS exhibited near-neutral stability. SEM–EDS imaging showed uniform surfaces for ASC.QDS, a rough texture for BER.QDS, and smooth morphology for GLU.QDS. TEM analysis revealed mean particle sizes of 8.06 nm for ASC.QDS, 7.13 nm for BER.QDS, and 5.12 nm for GLU.QDS, with varying morphologies and aggregation patterns. Among the three, GLU.QDS had the highest total phenolic content (TPC: 70.02%), followed by ASC.QDS (45.25%) and BER.QDS (23.71%). In antioxidant assays, BER.QDS demonstrated the strongest DPPH scavenging (IC₅₀ = 3.95&#xa0;µg/mL), while ASC.QDS exhibited the highest ABTS<sup>•+</sup> scavenging (57.88% at 80&#xa0;µg/mL). GLU.QDS displayed superior hemolysis stability (IC₅₀ = 7.17&#xa0;µg/mL) and α-amylase inhibition (IC₅₀ = 4.73&#xa0;µg/mL). Additionally, BER.QDS achieved the highest methylene blue degradation (29.01%), followed by ASC.QDS (23.57%) and GLU.QDS (22.22%). These findings underscore the multifunctionality of antioxidant-capped quantum dots, with BER.QDS demonstrating enhanced catalytic and antibacterial efficacy. This study provides a novel, holistic evaluation of their physicochemical and biomedical properties, paving the way for scalable synthesis and potential applications in sustainability and healthcare.</p> Graphical Abstract <p></p>

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Harnessing Biomedical Applications of Ascorbic Acid, Berberine, and Glutathione-Capped Quantum Dots Through Multifunctional Physico-chemical, Biochemical, and Anti-microbial Assays

  • 期刊论文

  • 发表日期：

    2025年3月7日

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  • Muhammad Anas,
  • Amjid Khan,
  • Aliza Falak,
  • Zabta Khan Shinwari,
  • Hamza Elsayed Ahmed Mohamed,
  • Khaoula Hkiri,
  • Malik Maaza,
  • Shah Fahad,
  • Umar Masood Quraishi

摘要

This study explores the physicochemical properties, bioactivity, and catalytic potential of quantum dots capped with ascorbic acid (ASC.QDS), berberine (BER.QDS), and glutathione (GLU.QDS) for biomedical and environmental applications. UV–Vis absorption spectra revealed distinct peaks, with ASC.QDS at ~ 350 nm, BER.QDS at lower intensity, and GLU.QDS exhibiting dual peaks at 280 nm and 350 nm. FTIR and Raman spectroscopy confirmed functional groups such as O–H, C = O, and C–H, indicating surface hydroxylation and functionalization across all samples. Zeta potential analysis suggested moderate stability for ASC.QDS (− 9.64 mV) and GLU.QDS (− 9.69 mV), whereas BER.QDS exhibited near-neutral stability. SEM–EDS imaging showed uniform surfaces for ASC.QDS, a rough texture for BER.QDS, and smooth morphology for GLU.QDS. TEM analysis revealed mean particle sizes of 8.06 nm for ASC.QDS, 7.13 nm for BER.QDS, and 5.12 nm for GLU.QDS, with varying morphologies and aggregation patterns. Among the three, GLU.QDS had the highest total phenolic content (TPC: 70.02%), followed by ASC.QDS (45.25%) and BER.QDS (23.71%). In antioxidant assays, BER.QDS demonstrated the strongest DPPH scavenging (IC₅₀ = 3.95 µg/mL), while ASC.QDS exhibited the highest ABTS•+ scavenging (57.88% at 80 µg/mL). GLU.QDS displayed superior hemolysis stability (IC₅₀ = 7.17 µg/mL) and α-amylase inhibition (IC₅₀ = 4.73 µg/mL). Additionally, BER.QDS achieved the highest methylene blue degradation (29.01%), followed by ASC.QDS (23.57%) and GLU.QDS (22.22%). These findings underscore the multifunctionality of antioxidant-capped quantum dots, with BER.QDS demonstrating enhanced catalytic and antibacterial efficacy. This study provides a novel, holistic evaluation of their physicochemical and biomedical properties, paving the way for scalable synthesis and potential applications in sustainability and healthcare.

Graphical Abstract