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<p>Global demand for joint replacement surgeries, musculoskeletal repairs, and orthodontics is on the rise, which drives emerging technologies to adapt to meet market demands. Although metallic biomaterials have a long history of application in the aerospace industry, their effectiveness within the biomedical area is only partially recognised. Despite their imperfect biocompatibility, metallic materials continue to be considered suitable for bone tissue substitutes and regenerative treatments because of their excellent mechanical qualities. In order to build the next generation of metallic biomaterials, improving biocompatibility is therefore the most crucial step. Titanium (Ti) and its alloys are mostly used in orthopaedic and dental applications because of its superior fatigue strength, low modulus of elasticity, high corrosion resistance, and outstanding formability.&#xa0;Ti is not suitable for long-term clinical uses due to its bioinert nature, and it cannot directly bind to living bone during the initial stages of implantation into a human body. For the enhancement of biological characteristics, several methods have been utilised. One surface treatment method that has generated a lot of interest is plasma electrolytic oxidation (PEO), which can provide bioactive, porous, and adhesive&#xa0;coatings for implantation. The biological assessment of coatings is summarised in this article. In-depth descriptions of the coating characteristics are given in this article in relation to the electrolyte, process parameters, pre-treatment, and post-treatment processes. The improved biocompatibility of PEO in comparison to other methods is also highlighted. Finally, authors outline the advantages and challenges of metallic biomaterials and make recommendations for further study.</p>

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Biocompatibility of Plasma Electrolytic Oxidation Coated Titanium Alloy for Biomedical Applications

  • 期刊论文

  • 发表日期：

    2025年2月11日

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  • Pralhad Pesode,
  • Shivprakash Barve

摘要

Global demand for joint replacement surgeries, musculoskeletal repairs, and orthodontics is on the rise, which drives emerging technologies to adapt to meet market demands. Although metallic biomaterials have a long history of application in the aerospace industry, their effectiveness within the biomedical area is only partially recognised. Despite their imperfect biocompatibility, metallic materials continue to be considered suitable for bone tissue substitutes and regenerative treatments because of their excellent mechanical qualities. In order to build the next generation of metallic biomaterials, improving biocompatibility is therefore the most crucial step. Titanium (Ti) and its alloys are mostly used in orthopaedic and dental applications because of its superior fatigue strength, low modulus of elasticity, high corrosion resistance, and outstanding formability. Ti is not suitable for long-term clinical uses due to its bioinert nature, and it cannot directly bind to living bone during the initial stages of implantation into a human body. For the enhancement of biological characteristics, several methods have been utilised. One surface treatment method that has generated a lot of interest is plasma electrolytic oxidation (PEO), which can provide bioactive, porous, and adhesive coatings for implantation. The biological assessment of coatings is summarised in this article. In-depth descriptions of the coating characteristics are given in this article in relation to the electrolyte, process parameters, pre-treatment, and post-treatment processes. The improved biocompatibility of PEO in comparison to other methods is also highlighted. Finally, authors outline the advantages and challenges of metallic biomaterials and make recommendations for further study.