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<p>Nanobiotechnology is a grow-fast applied science that has established straightforward shots in medicine, agriculture, and industry. Herein, a proceeding investigation on the myco-synthesis of selenium nanoparticles (SeNPs) using endophytic <i>Aspergillus candidus</i> ethyl acetate (ACE) extract&#xa0;was conducted. Biosynthesized SeNPs were characterized and examined along with ACE extract for their antibacterial and cytotoxic potency, in addition to analyzing the phyto-constituents of ACE extract by high-performance liquid chromatography (HPLC). HPLC analysis revealed the majority of gallic and chlorogenic acids in ACE extract. TEM analysis exhibited an average particle size of 13.9 nm, while XRD analysis revealed an average size of 16.4 nm in a pure crystalline trigonal crystallographic system. The zeta potential value was found to be − 42.96 mV with the hydrodynamic particle of 108.58 nm. ACE extract and its biofabricated SeNPs exhibited weak cytotoxicity against the HCT-116 cell line. Fungal extracts and their biosynthesized nanoparticles with diverse bioactivities are considered prospective horizons in biotechnological applications<i>.</i> SeNPs demonstrated distinguished antimicrobial activity against a range of bacterial strains, including Gram-positive, Gram-negative, and multidrug-resistant (MDR) strains, outperforming both ACE extracts and the antibiotic cefotaxime. They were particularly effective at higher concentrations (150–200 μg/mL) and displayed lower minimum inhibitory concentration (MIC) values, making them effective at lower doses.</p> Graphical Abstract <p></p>

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Facile Mycosynthesis of Selenium Nanoparticles by Aspergillus candidus Extract: Unveiling Characterization, Potent Antimicrobial Properties, and Cytotoxic Activities

  • 期刊论文

  • 发表日期：

    2025年2月12日

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  • Bandar R. Alsehli,
  • Mostafa F. Al-Hakkani,
  • Abdullah H. Alluhayb,
  • Sayed M. Saleh,
  • Hassan Mohamed,
  • Abdallah M. A. Hassane,
  • Mohammad H. A. Hassan

摘要

Nanobiotechnology is a grow-fast applied science that has established straightforward shots in medicine, agriculture, and industry. Herein, a proceeding investigation on the myco-synthesis of selenium nanoparticles (SeNPs) using endophytic Aspergillus candidus ethyl acetate (ACE) extract was conducted. Biosynthesized SeNPs were characterized and examined along with ACE extract for their antibacterial and cytotoxic potency, in addition to analyzing the phyto-constituents of ACE extract by high-performance liquid chromatography (HPLC). HPLC analysis revealed the majority of gallic and chlorogenic acids in ACE extract. TEM analysis exhibited an average particle size of 13.9 nm, while XRD analysis revealed an average size of 16.4 nm in a pure crystalline trigonal crystallographic system. The zeta potential value was found to be − 42.96 mV with the hydrodynamic particle of 108.58 nm. ACE extract and its biofabricated SeNPs exhibited weak cytotoxicity against the HCT-116 cell line. Fungal extracts and their biosynthesized nanoparticles with diverse bioactivities are considered prospective horizons in biotechnological applications. SeNPs demonstrated distinguished antimicrobial activity against a range of bacterial strains, including Gram-positive, Gram-negative, and multidrug-resistant (MDR) strains, outperforming both ACE extracts and the antibiotic cefotaxime. They were particularly effective at higher concentrations (150–200 μg/mL) and displayed lower minimum inhibitory concentration (MIC) values, making them effective at lower doses.

Graphical Abstract