Scholarlink

<p>The research focuses on the synthesis and characterization of chitosan nanoparticles derived from the cuttlebone of <i>Sepia prashadi</i>. The primary objective is to evaluate the effectiveness of these nanoparticles in combating cancer within the MG63 human osteosarcoma cell line. Healthcare professionals create chitosan, a naturally derived compound, by extracting a portion from cuttlebone. Chitosan nanoparticles were produced through a technique known as ionic gelation, which is a widely used method for forming stable nanoparticles. We employed various techniques such as Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray diffraction (XRD) to evaluate the quality of the nanoparticles we synthesized. The tests confirmed the proper synthesis, stability, appropriate size distribution, and uniform surface of the nanoparticles. Tests evaluating the ability of nanoparticles to target cancer were carried out in a laboratory with MG63 cell lines. These assessments examined the toxicological properties of the nanoparticles and their prospective use in medical treatments. The results showed that as the dose increased, fewer cells survived, suggesting a potential anti-cancer effect. The findings suggest that chitosan nanoparticles derived from <i>S. prashadi</i> cuttlebone show great promise as a safe and eco-friendly source for cancer treatment.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Synthesis, Characterization of Chitosan Nanoparticles from Cuttlebone of Sepia prashadi and Its Anticancer Efficacy Against MG63 Cell Line

  • 期刊论文

  • 发表日期：

    2025年2月1日

查看全文
  • Chithambara Shathviha Palaniappan,
  • Annathai Pitchai,
  • Revathi Duraisamy,
  • Dhanraj Ganapathy,
  • Pasiyappazham Ramasamy

摘要

The research focuses on the synthesis and characterization of chitosan nanoparticles derived from the cuttlebone of Sepia prashadi. The primary objective is to evaluate the effectiveness of these nanoparticles in combating cancer within the MG63 human osteosarcoma cell line. Healthcare professionals create chitosan, a naturally derived compound, by extracting a portion from cuttlebone. Chitosan nanoparticles were produced through a technique known as ionic gelation, which is a widely used method for forming stable nanoparticles. We employed various techniques such as Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray diffraction (XRD) to evaluate the quality of the nanoparticles we synthesized. The tests confirmed the proper synthesis, stability, appropriate size distribution, and uniform surface of the nanoparticles. Tests evaluating the ability of nanoparticles to target cancer were carried out in a laboratory with MG63 cell lines. These assessments examined the toxicological properties of the nanoparticles and their prospective use in medical treatments. The results showed that as the dose increased, fewer cells survived, suggesting a potential anti-cancer effect. The findings suggest that chitosan nanoparticles derived from S. prashadi cuttlebone show great promise as a safe and eco-friendly source for cancer treatment.